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BCHE

概要

Name:Butyrylcholinesterase
Target Synonym:BCHED,CHE2,E1,Butyrylcholinesterase,BuChE,EC:3.1.1.8,EC 3.1.1,BCHE,Acylcholine acylhydrolase,Pseudocholinesterase,Cholinesterase,CHE1,Cholinesterase (Serum) 2,Butyrylcholine Esterase,Choline Esterase II,Cholinesterase 1,EC 3.1.1.8
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase 3 Clinical

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BHE-H52H3 Human Human BCHE / Butyrylcholinesterase Protein, His Tag (active enzyme)
BHE-H52H3-structure
BHE-H52H3-sds
ACRO Quality

Synonym Name

Acylcholine acylhydrolase; BCHE; Butyrylcholine esterase; Butyrylcholinesterase; CHE1; CHE1cholinesterase; Choline esterase II; cholinesterase 1; E1; EC 3.1.1.8; Pseudocholinesterase

Background

BCHE (also known as Butyrylcholinesterase,  pseudocholinesterase, plasma cholinesterase, or BuChE) is a nonspecific cholinesterase enzyme that hydrolyzes many different choline esters. Both acetylcholinesterase and butyrylcholinesterase represent therapeutic targets for ameliorating the cholinergic deficit considered to be responsible for the declines in cognitive, behavioral and global functioning characteristic of Alzheimer's disease (AD).

Clinical and Translational Updates

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
Octahydroaminoacridine succinate 华洋-001 Phase 3 Clinical Changchun Huayang High-Tech Co Ltd, Jiangsu Sheneryang High-Tech Co Ltd Alzheimer Disease Details
Benzgalantamine GLN-1062; ALPHA-1062; ALPHA-1062IN Phase 2 Clinical Galantos Pharma GmbH Brain Injuries, Traumatic; Alzheimer Disease Details
Bisnorcymserine ANVS-301 Phase 1 Clinical Horizon Therapeutics PLC Alzheimer Disease Details
Octahydroaminoacridine succinate 华洋-001 Phase 3 Clinical Changchun Huayang High-Tech Co Ltd, Jiangsu Sheneryang High-Tech Co Ltd Alzheimer Disease Details
Benzgalantamine GLN-1062; ALPHA-1062; ALPHA-1062IN Phase 2 Clinical Galantos Pharma GmbH Brain Injuries, Traumatic; Alzheimer Disease Details
Bisnorcymserine ANVS-301 Phase 1 Clinical Horizon Therapeutics PLC Alzheimer Disease Details

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