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Mucin-1

概要

Name:Mucin-1
Target Synonym:PEM,Medullary Cystic Kidney Disease 1 (Autosomal Dominant),Tumor Associated Epithelial Mucin,CD227 Antigen,H23 Antigen,MUC-1/SEC,ADMCKD1,Cancer antigen 15-3,Tumor-associated mucin,MUC1-alpha,MUC1-beta,MUC-1/X,MUC1/ZD,Mucin-1,ADMCKD,MCKD1,MAM6,MCKD,MCD,Polymorphic epithelial mucin,PUM,MUC1-NT,Episialin,CD227,MUC1-CT,MUC1,Mucin 1, Cell Surface Associated,Tumor-Associated Epithelial Membrane Antigen,Peanut-Reactive Urinary Mucin,Carcinoma-Associated Mucin,Krebs Von Den Lungen-6,CA 15-3,H23AG,MUC-1,
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:21
Lastest Research Phase:Phase 2 Clinical

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ACRO Quality

生物活性データの一部

MU1-HA2H8-Cell-based assay
 Mucin-1 FACS

5e5 of anti-Mucin-1 (F1C) CAR-293 cells were stained with 100 μL of 1:50 dilution (2 μL stock solution in 100 μL FACS buffer) of APC-Labeled Human Mucin-1 Protein, His Tag (Cat. No. MU1-HA2H8) and negative control protein respectively. APC signal was used to evaluate the binding activity (QC tested).

MU1-H82E5-Cell-based assay
 Mucin-1 FACS

2e5 of Anti-Mucin-1 CAR-293 cells were stained with 100 μL of 0.1 μg/mL of Biotinylated Human Mucin-1, His,Avitag (Cat. No. MU1-H82E5) and negative control protein respectively, washed and then followed by PE-SA and analyzed with FACS (Routinely tested).

MU1-H5254-ELISA
Human Mucin-1 (24-380), Fc TagHuman Mucin-1 (24-380), Fc Tag (Cat. No. MU1-H5254) ELISA bioactivity

Immobilized Human Mucin-1 (24-380), Fc Tag (Cat. No. MU1-H5254) at 2 μg/mL (100 μL/well) can bind Monoclonal Anti-Mucin-1 Antibody, Mouse IgG1 (SM-3) with a linear range of 0.5-4 ng/mL (QC tested).

MU1-H52H7-MALS-HPLC
Mucin-1 MALS images

The purity of Human Mucin-1 (24-380) Protein, His Tag (Cat. No. MU1-H52H7) is more than 90% and the molecular weight of this protein is around 45-65 kDa verified by SEC-MALS.

Synonym Name

Mucin 1,MUC1,CD227,EMA,H23AG,KL-6,MAM6,MUC-1,SEC,MUC-1,X,MUC1,ZD,PEM,PEMT,PUM,CA15-3,Episialin

Background

Membrane mucins have several functions in epithelial cells including cytoprotection, extravasation during metastases, maintenance of luminal structure, and signal transduction. MUC17, contains an extended, repetitive extracellular glycosylation domain and a carboxyl terminus with two EGF-like domains, a SEA module domain, a transmembrane domain, and a cytoplasmic domain with potential serine and tyrosine phosphorylation sites. Interacts via its C-terminus with PDZK1 and this interaction appears important for proper localization. Probably plays a role in maintaining homeostasis on mucosal surfaces.

Clinical and Translational Updates

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
Anti-MUC1 CAR T cell (Guangzhou Anjie Biomedical) Phase 2 Clinical Guangzhou Anjie Biomedical Technology Esophageal Neoplasms; Breast Neoplasms; Prostatic Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Gatipotuzumab GT-MAB-2.5-GEX Phase 1 Clinical Nemod, Glycotope Gmbh Solid tumours; Carcinoma, Ovarian Epithelial; Peritoneal Neoplasms; Fallopian Tube Neoplasms Details
Anti MUC 1 chimeric antigen receptor T cell therapy (Innovative Cellular) Phase 1 Clinical Innovative Cellular Therapeutics Co Ltd Pancreatic Neoplasms; Breast Neoplasms; Lung Neoplasms Details
Cancer vaccine (BN ImmunoTherapeutics/National Cancer Institute) CVAC-301; CV-301 Phase 2 Clinical Therion Biologics Ovarian Neoplasms; Cystadenocarcinoma; Intestinal Neoplasms; Solid tumours; Pancreatic Neoplasms; Urinary Bladder Neoplasms; Breast Neoplasms; Prostatic Neoplasms; Colorectal Neoplasms; Carcinoma, Squamous Cell; Carcinoma, Pancreatic Ductal; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma; Neoplasm Metastasis; Melanoma Details
BromAc Phase 2 Clinical Mucpharm Pty Ltd Coronavirus Disease 2019 (COVID-19); Pneumonia, Ventilator-Associated Details
BLP25 liposome vaccine BLP-25; L-BLP25; ONO-7165; LP-BLP-25; EMD-531444 Phase 2 Clinical Cascadian Therapeutics Inc Rectal Neoplasms; Multiple Myeloma; Breast Neoplasms; Prostatic Neoplasms; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung Details
huMNC2-CAR44 huMNC2-CAR44 Phase 1 Clinical Minerva Biotechnologies Breast Neoplasms Details
P-MUC1C-ALLO1 P-MUC1C-ALLO1; P-MUC1C-101 Phase 1 Clinical Poseida Therapeutics Inc Solid tumours; Ovarian Neoplasms; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Pancreatic Neoplasms; Nasopharyngeal Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
DS-3939 DS-3939; DS-3939a Phase 2 Clinical Daiichi Sankyo Inc Solid tumours; Neoplasm Metastasis Details
MUC1-Poly-ICLC MUC1-poly-ICLC Phase 2 Clinical University Of Pittsburgh Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
MUC1-peptide-DC-CTL (Beijing Doing Biomedical) Phase 1 Clinical Beijing Doing Biomedical Co Ltd Stomach Neoplasms Details
MUC1-gene-DC-CTL (Beijing Doing Biomedical) Phase 1 Clinical Beijing Doing Biomedical Co Ltd Stomach Neoplasms Details
ICTCAR-046 ICTCAR-046 Clinical Innovative Cellular Therapeutics Co Ltd Pancreatic Neoplasms Details
Adenoviral MUC1 vaccine (Etubics) ETBX-061; Ad5-MUC1 Phase 2 Clinical Etubics Corp, Immunitybio Inc, Nantkwest Inc Breast Neoplasms; Melanoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Carcinoma, Squamous Cell; Lung Neoplasms; Lymphoma, Non-Hodgkin; Colorectal Neoplasms; Prostatic Neoplasms; Ovarian Neoplasms; Chordoma; Carcinoma, Transitional Cell; Neoplasms; Triple Negative Breast Neoplasms; Colonic Neoplasms; Pancreatic Neoplasms; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Merkel Cell Details
Recombinant HSP-MUC1 fusion protein (Newsummit) Phase 1 Clinical Shanghai Xinshengyuan Biological Medicine Co Ltd Breast Neoplasms Details
DXC-005 DXC-005 Phase 1 Clinical Hangzhou Dac Biotech Company Ltd Solid tumours Details
BM7PE Phase 2 Clinical Oslo University Hospital Colorectal Neoplasms Details
Anti-MUC1 monoclonal antibody (OncoQuest) AR20.5; mAb-AR20.5; Anti-MUC1 AR20.5 Phase 2 Clinical Altarex Pancreatic Neoplasms Details
GO-2032c GO-203-2C Phase 2 Clinical Genus Oncology Llc, Dana-Farber Cancer Institute Solid tumours; Multiple Myeloma; Leukemia, Myeloid, Acute Details
M-1231 M-1231 Phase 1 Clinical Emd Serono Research & Development Institute Inc, Merck Serono Solid tumours; Esophageal Neoplasms; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung Details
Anti-MUC1 CAR T-cell therapy (Guangzhou Anjie Biomedical Technology/University of Technology Sydney) Phase 2 Clinical The First Affiliated Hospital Of Guangdong Pharmaceutical University, Guangzhou Anjie Biomedical Technology, University of Sydney Carcinoma, Non-Small-Cell Lung Details

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