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Transferrin

概要

Name:Tissue factor
Target Synonym:Coagulation Factor III (Thromboplastin, Tissue Factor),Thromboplastin,Coagulation Factor III, Tissue Factor,TFA,F3,TF,CD142 Antigen,CD142,Coagulation Factor III,Tissue Factor
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Approved

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生物活性データの一部

CHEK-ATP115-Cell-based assay
 Transferrin FACS

Expression analysis of human Transferrin on HEK293/Human Transferrin Stable Cell Line by FACS.
Cell surface staining was performed on HEK293/Human Transferrin Stable Cell Line or negative control cell using PE-labeled anti-human Transferrin antibody.

TRN-H82E3-SPR
 Transferrin SPR

Biotinylated Human Transferrin Protein, His,Avitag (Cat. No. TRN-H82E3) captured on Biotin CAP-Series S Sensor Chip can bind Human Transferrin R, His Tag (Cat. No. CD1-H5243) with an affinity constant of 0.527 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

TRN-H5216-ELISA
 Transferrin ELISA

Immobilized Human Transferrin Protein, premium grade (Cat. No. TRN-H5216) at 2 μg/mL (100 μL/well) can bind Biotinylated Human Transferrin R, Avitag,His Tag (Cat. No. TFR-H82E5) with a linear range of 1-16 ng/mL (QC tested).

Synonym Name

Transferrin,TF,DKFZp781D0156,PRO1557,PRO2086

Background

Transferrin is also known as Serotransferrin, Beta-1 metal-binding globulin, TF, and is iron-binding blood plasma glycoproteins that control the level of free iron in biological fluids. Although iron bound to transferrin is less than 0.1% (4

相関分子

公開薬物情報

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Tisotumab vedotin TF-011-MMAE Approved Genmab A/S HuMax-TF, TIVDAK United States Uterine Cervical Neoplasms Seagen Inc 2021-09-20 Ovarian Neoplasms; Solid tumours; Esophageal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Pancreatic Neoplasms; Urinary Bladder Neoplasms; Prostatic Neoplasms; Peritoneal Neoplasms; Colorectal Neoplasms; Endometrial Neoplasms; Fallopian Tube Neoplasms; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Tisotumab vedotin TF-011-MMAE Approved Genmab A/S HuMax-TF, TIVDAK United States Uterine Cervical Neoplasms Seagen Inc 2021-09-20 Ovarian Neoplasms; Solid tumours; Esophageal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Pancreatic Neoplasms; Urinary Bladder Neoplasms; Prostatic Neoplasms; Peritoneal Neoplasms; Colorectal Neoplasms; Endometrial Neoplasms; Fallopian Tube Neoplasms; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung Details

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
Anpocogin AB-201 Phase 3 Clinical Dendreon Uk Ltd Coronavirus Disease 2019 (COVID-19) Details
XNW-28012 XNW-28012; XNW28012 Phase 2 Clinical Shanghai Cigna Biotech Pharmaceutical Co Ltd Solid tumours Details
MRG-004A MRG004A Phase 2 Clinical Solid tumours Details
XB-002 XB-002; ICON-2 Phase 1 Clinical Iconic Therapeutics Inc Solid tumours; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Ovarian Epithelial; Triple Negative Breast Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Breast Neoplasms; Urogenital Neoplasms; Esophageal Squamous Cell Carcinoma; Endometrial Neoplasms; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms Details
Anpocogin AB-201 Phase 3 Clinical Dendreon Uk Ltd Coronavirus Disease 2019 (COVID-19) Details
XNW-28012 XNW-28012; XNW28012 Phase 2 Clinical Shanghai Cigna Biotech Pharmaceutical Co Ltd Solid tumours Details
MRG-004A MRG004A Phase 2 Clinical Solid tumours Details
XB-002 XB-002; ICON-2 Phase 1 Clinical Iconic Therapeutics Inc Solid tumours; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Ovarian Epithelial; Triple Negative Breast Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Breast Neoplasms; Urogenital Neoplasms; Esophageal Squamous Cell Carcinoma; Endometrial Neoplasms; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms Details

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