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Your Position: ホーム > Thrombopoietin

Thrombopoietin

概要

Name:Thrombopoietin
Target Synonym:Prepro-Thrombopoietin,MPL Ligand,MGDF,THCYT1,MKCSF,MPLLG,TPO,Thrombopoietin,THPO,Megakaryocyte colony-stimulating factor,Megakaryocyte growth and development factor,C-mpl ligand,ML,Myeloproliferative Leukemia Virus Oncogene Ligand,Megakaryocyte Stimulating Factor,Thrombopoietin Nirs Variant 1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Discontinued

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製造番号 種類 製品説明 構造 純度 特徴
THN-H5216 Human Human Thrombopoietin / TPO Protein, premium grade
THN-H5216-structure
THN-H5216-sds
GMP-THNH25 Human GMP Human Thrombopoietin Protein
GMP-THNH25-structure
THN-H5214 Human Human Thrombopoietin / TPO Protein, Tag Free
THN-H5214-structure
THN-H5214-sds
ACRO Quality

生物活性データの一部

THN-H5216-Cell-based assay
Thrombopoietin CELL

Human Thrombopoietin Protein, premium grade (Cat. No. THN-H5216) stimulates proliferation of Mo7e cells. The specific activity of Human Thrombopoietin Protein, premium grade is > 1.00ⅹ10^7 IU/mg, which is calibrated against human TPO Standard (NIBSC code: 03/124) (QC tested).

Protocol
THN-H5214-Cell-based assay
Thrombopoietin CELL

Human Thrombopoietin Protein, Tag Free (Cat. No. THN-H5214) stimulates proliferation of Mo7e cells. The specific activity of Human Thrombopoietin Protein, Tag Free is > 1.0ⅹ10^7 IU/mg (Routinely tested).

Protocol
THN-H5214-SPR
Thrombopoietin SPR

Human Thrombopoietin R, His Tag (Cat. No. THR-H52H7) captured on CM5 Chip via anti-His antibody can bind Human Thrombopoietin Protein, Tag Free (Cat. No. THN-H5214) with an affinity constant of 14.9 nM as determined in SPR assay (Biacore T200) (Routinely tested).

Protocol
THN-H5216-MALS-HPLC
Thrombopoietin MALS images

The purity of Human Thrombopoietin Protein, premium grade (Cat. No. THN-H5216) is more than 90% and the molecular weight of this protein is around 65-85 kDa verified by SEC-MALS.

Synonym Name

Thrombopoietin,MKCSF,THPO,TPO,C-mpl ligand,MGDF

Background

Thrombopoietin (TPO) is a 332 amino acid glycoprotein made primarily in the liver and act as the major physiological regulator of platelet production. TPO binds the TPO receptor, activates JAK and STAT pathways, thus stimulating megakaryocyte growth and platelet production. Additionally, further investigation uncovered that thrombopoietin is a critical cytokine promoting hematopoietic rebound after myeloablation and its transcripts are expressed by multiple cellular sources.

Clinical and Translational Updates

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