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Your Position: ホーム > IL-17A & IL-17F

IL-17A & IL-17F

概要

Name:Interleukin 17A
Target Synonym:Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8),CTLA8,IL17A,Interleukin 17A,Cytotoxic T-Lymphocyte-Associated Antigen 8,Cytotoxic T-Lymphocyte-Associated Protein 8,CTLA-8,IL-17A,IL-17,IL17,Interleukin-17A
Number of Launched Drugs:3
Number of Drugs in Clinical Trials:29
Lastest Research Phase:Approved

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製造番号 種類 製品説明 構造 純度 特徴
ILF-H52W6 Human Human IL-17A&IL-17F Heterodimer Protein, Twin Strep&His Tag (MALS verified)
ILF-H52W6-structure
ILF-H52W6-sds
ILF-H82W1 Human Biotinylated Human IL-17A&IL-17F Protein, Avitag™,His Tag
ILF-H82W1-structure
ILF-H82W1-sds
ACRO Quality

生物活性データの一部

ILF-H52W6-Cell-based assay
IL-17A & IL-17F CELL

Human IL-17A&IL-17F Heterodimer Protein, Twin Strep&His Tag (Cat. No. ILF-H52W6) stimulates production of IL-6 in NIH-3T3 cells in the presence of 200 ng/mL human TNF-alpha. The EC50 for this effect is 11.34-12.46 ng/mL (Routinely tested).

Protocol
ILF-H52W6-SPR
IL-17A & IL-17F SPR

Human IL17RA & IL17RC Protein, Fc Tag&Fc Tag (Cat. No. ILC-H5257) captured on CM5 chip via anti-human IgG Fc antibody can bind Human IL-17A&IL-17F Heterodimer Protein, Twin Strep&His Tag (Cat. No. ILF-H52W6) with an affinity constant of 50.8 pM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol
ILF-H52W6-BLI
IL-17A & IL-17F BLI

Loaded Human IL-17 RA, Fc Tag (Cat. No. ILA-H5257) on Protein A Biosensor, can bind Human IL-17A&IL-17F Heterodimer Protein, Twin Strep&His Tag (Cat. No. ILF-H52W6) with an affinity constant of 3.70 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol

IL-17A & IL-17F Molecule Synonym Name

IL-17A,Interleukin-17A,CTLA-8,IL-17,IL-17F,Interleukin-17F,Cytokine ML-1

IL-17A & IL-17F Molecule Background

Interleukin-17A (IL17A) is also known as cytotoxic T-lymphocyte-associated antigen 8 (CTLA8),which is a proinflammatory cytokine produced by activated T cells. IL17A can regulate the activities of NF-kappaB and mitogen-activated protein kinases. Also,IL17A can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO).Furthermore,IL17A has been found both in glycosylated and nonglycosylated forms. High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

IL-17A & IL-17F References

公開薬物情報

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Ixekizumab LY-2439821 Approved Eli Lilly And Company 拓咨, Taltz United States Psoriasis Eli Lilly And Company 2016-03-22 Diabetes Mellitus, Type 1; Non-radiographic axial spondyloarthritis; Depressive Disorder, Major; Pyoderma Gangrenosum; Spondylarthritis; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis; Arthritis, Psoriatic; Lichen Planus; Pemphigoid, Bullous; Pityriasis Rubra Pilaris; Plaque psoriasis Details
Virulizin Approved Aptose Virulizin, Virulizin-2 gamma Mexico Sarcoma, Kaposi; Melanoma; Carcinoma, Renal Cell; Colorectal Neoplasms; Stomach Neoplasms; Pancreatic Neoplasms; Uterine Cervical Neoplasms null 1997-01-01 Carcinoma, Renal Cell; Stomach Neoplasms; Pancreatic Neoplasms; Colorectal Neoplasms; Sarcoma, Kaposi; Melanoma; Uterine Cervical Neoplasms Details
Secukinumab NVP-AIN-457; AIN-457; KB-03303A Approved Novartis Pharma Ag 可善挺, Scapho, Cosentyx Japan Arthritis, Psoriatic; Psoriasis Novartis Pharma Ag 2014-12-26 Hidradenitis Suppurativa; Polymyalgia Rheumatica; Ichthyosis, Lamellar; Psoriasis; Tendinopathy; Hyperkeratosis, Epidermolytic; Arthritis, Psoriatic; Tendon Injuries; Asthma; Lichen Planus; Arthritis, Juvenile; Uveitis; Arthritis; Inflammation; Plaque psoriasis; Behcet Syndrome; Crohn Disease; Gastroenteritis; Dermatitis, Atopic; Ichthyosiform Erythroderma, Congenital; Spondylitis, Ankylosing; Non-radiographic axial spondyloarthritis; Necrobiosis Lipoidica; Diabetes Mellitus, Type 1; Giant Cell Arteritis; Alopecia Areata; Pyoderma Gangrenosum; Lupus Erythematosus, Discoid; Metabolic Dysfunction-Associated Steatotic Liver Disease; Inflammatory Bowel Diseases; Multiple Sclerosis, Relapsing-Remitting; Rotator Cuff Injuries; Spondylarthritis; Arthritis, Rheumatoid; Spondylarthropathies; Netherton Syndrome; Ichthyosis; Lupus Nephritis; Graves Ophthalmopathy; Multiple Sclerosis Details

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
SSGJ-608 608; SSGJ-608 Phase 3 Clinical Sunshine GuoJian Pharmaceutical (Shanghai) Co Ltd Non-radiographic axial spondyloarthritis; Spondylitis, Ankylosing; Spondylarthritis; Psoriasis; Plaque psoriasis Details
QX002N QX-002N Phase 3 Clinical Qyuns Therapeutics Co Ltd Spondylitis, Ankylosing; Asthma Details
Roconkibart JS005 Phase 3 Clinical Shanghai Junshi Biosciences Co Ltd Non-radiographic axial spondyloarthritis; Spondylarthritis; Spondylitis, Ankylosing; Psoriasis; Plaque psoriasis Details
Gumokimab AK-111 Phase 3 Clinical Zhongshan Akeso Biopharma Co Ltd Non-radiographic axial spondyloarthritis; Spondylarthritis; Spondylitis, Ankylosing; Skin Diseases; Psoriasis; Plaque psoriasis Details
Izokibep IMG-020; IMG020; ABY-035; AFB-035 Phase 3 Clinical Affibody Ab Non-radiographic axial spondyloarthritis; Spondylitis, Ankylosing; Psoriasis; Arthritis, Psoriatic; Hidradenitis Suppurativa; Uveitis; Plaque psoriasis Details
Recombinant human IL-17A/F humanized antibody (Livzon Pharmaceutical Group) LZM－012; LZM012; XKH004; XKH-004 Phase 3 Clinical Beijing Kanova Biomedical Technology Co Ltd, Livzon Pharmaceutical Group Inc Spondylitis, Ankylosing; Psoriasis; Plaque psoriasis Details
Secukinumab biosimilar (Bio-Thera Solutions) BAT-2306 Phase 3 Clinical Bio-Thera Solutions Ltd Autoimmune Diseases; Psoriasis; Plaque psoriasis Details
DMT-310 DMT-310 Phase 3 Clinical Dermata Acne Vulgaris; Rosacea Details
CJM-112 CJM-112 Phase 2 Clinical Novartis Pharma Ag Acne Vulgaris; Triple Negative Breast Neoplasms; Multiple Sclerosis; Multiple Myeloma; Psoriasis; Asthma; Colorectal Neoplasms; Hidradenitis Suppurativa; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma Details
Sonelokimab M-1095; ALX-0761; MSB-0010841 Phase 2 Clinical Ablynx Nv Psoriasis; Arthritis, Psoriatic; Hidradenitis Suppurativa Details
SIM-0335 SIM-0335; SIM-335 Phase 2 Clinical BCY Pharm Co Ltd Plaque psoriasis Details
SCT-650C SCT650C; SCT-650-C; SCT-650C Phase 2 Clinical SinoCelltech Ltd Non-radiographic axial spondyloarthritis; Autoimmune Diseases; Plaque psoriasis Details
Isomyosamine MYMD-1 Phase 2 Clinical Mymd Pharmaceuticals Inc Depression; Anxiety; Hashimoto Disease; Frailty; Coronavirus Disease 2019 (COVID-19); Arthritis, Rheumatoid; Healthy Aging; Inflammation; Sarcopenia Details
CNTO-6785 CNTO-6785; FTC-001 Phase 1 Clinical Morphosys Ag, Johnson & Johnson Innovative Medicine Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis; Arthritis, Psoriatic; Pulmonary Disease, Chronic Obstructive Details
JNJ-61178104 JNJ-61178104 Phase 1 Clinical Johnson & Johnson Innovative Medicine Autoimmune Diseases Details
Secukinumab biosimilar (BioRay Pharmaceutical) BR-201 Phase 1 Clinical BioRay Pharmaceutical Co Ltd Autoimmune Diseases; Spondylitis, Ankylosing; Psoriasis; Plaque psoriasis Details
JNJ-63823539 JNJ-63823539 Phase 1 Clinical Johnson & Johnson Innovative Medicine Arthritis, Rheumatoid Details
Secukinumab Biosimilar(Celltrion) CT-P55 Phase 1 Clinical Celltrion Inc Plaque psoriasis Details
Secukinumab biosimilar (CSPC Pharmaceutical Group) SYS6012; SYS-6012 Phase 1 Clinical CSPC Pharmaceutical Group Ltd Plaque psoriasis Details
Secukinumab biosimilar (Gan & Lee) GLR1023; GLR-1023 Phase 1 Clinical Gan & Lee Pharmaceuticals Plaque psoriasis Details
anti-IL-17A humanized monoclonal antibody(Fontacea ) Phase 1 Clinical Shandong Fangtansi Biopharmaceutical Co Ltd Plaque psoriasis Details
CMAB-015 CMAB015; CMAB-015 Phase 1 Clinical Taizhou Mabtech Pharmaceutical Co Ltd Spondylitis, Ankylosing; Plaque psoriasis Details
DC-853 DC-853 Phase 1 Clinical Dice Therapeutics Inc Immune System Diseases Details
LEO-153339 LEO-153339 Phase 1 Clinical Leo Pharma Inc Details
HY-1770 HY1770; HT-17; HT17; HY-1770 Phase 1 Clinical Suzhou Pharmavan Co Ltd Dermatitis, Atopic; Plaque psoriasis Details
ZL-1102 ZL-1102; CB-001 Phase 1 Clinical Crescendo Biologics Ltd, Zai Lab (Shanghai) Co Ltd Psoriasis Details
UCB-0159 UCB-0159 Phase 1 Clinical Ucb Sa Autoimmune Diseases Details

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