ログイン 会員登録
icon_bulk_order一括注文 Acrobiosystems for English
Promotion
Recombinantタンパク質s ClearClear history
Recombinantタンパク質s CloseClose
Browse Products By Molecule Name a-zA-Z
TL1A Hot |GMP IL-2 Hot |FcRn Binding Kit (TR-FRET) New |Claudin 18.2
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
phone
Your Position: ホーム > Siglec-10

Siglec-10

概要

Name:Sialic acid-binding Ig-like lectin 10
Target Synonym:UNQ477/PRO940,SIGLEC10,Sialic Acid Binding Ig Like Lectin 10,Sialic Acid Binding Ig-Like Lectin 10 Ig-Like Lectin 7,Siglec-Like Protein 2,Siglec-Like Gene 2,SLG2,Sialic Acid-Binding Ig-Like Lectin 10,Sialic Acid Binding Ig-Like Lectin 10,Siglec-10,PRO940,MGC126774
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Phase 3 Clinical

製品リスト製品比較と製品注文

製品> フィルター結果
製品仕様別：
製品カテゴリー別：
種類別：
タグ別：
コンジュゲート：
製造番号 種類 製品説明 構造 純度 特徴
SI0-C82E5 Cynomolgus Biotinylated Cynomolgus Siglec-10 Protein, His,Avitag™ (MALS verified)
SI0-C82E5-structure
SI0-C82E5-sds
SI0-H5255 Human Human Siglec-10 Protein, Fc (L118A, G120A, E201A) Tag
SI0-H5255-structure
SI0-H5255-sds
SI0-H5254 Human Human Siglec-10 Protein, Fc (L117A, L118A) Tag
SI0-H5254-structure
SI0-H5254-sds
SI0-C52H5 Cynomolgus Cynomolgus Siglec-10 Protein, His Tag (MALS verified)
SI0-C52H5-structure
SI0-C52H5-sds
SI0-HP2E5 Human PE-Labeled Human Siglec-10 Protein, His Tag (recommended for neutralizing assay) (Site-specific conjugation)
SI0-HP2E5-structure
SI0-H82E3 Human Biotinylated Human Siglec-10 Protein, His,Avitag™
SI0-H82E3-structure
SI0-H82E3-sds
SI0-H82F6 Human Biotinylated Human Siglec-10 Protein, Fc,Avitag™ (MALS verified)
SI0-H82F6-structure
SI0-H82F6-sds
SI0-M52H7 Mouse Mouse Siglec-10 Protein, His Tag
SI0-M52H7-structure
SI0-M52H7-sds
SI0-H52H9 Human Human Siglec-10 Protein, His Tag (MALS verified)
SI0-H52H9-structure
SI0-H52H9-sds
SI0-H5253 Human Human Siglec-10 Protein, Fc Tag
SI0-H5253-structure
SI0-H5253-sds
SI0-H525b Human Human Siglec-10 Protein, Mouse IgG2a Fc Tag, low endotoxin
SI0-H525b-structure
SI0-H525b-sds
ACRO Quality

生物活性データの一部

SI0-HP2E5-Cell-based assay
Siglec-10 FACS

2e5 of 293 cells overexpressing human CD24 were stained with 100μL of 1:10 dilution of PE-Labeled Human Siglec-10 Protein, His Tag(recommended for neutralizing assay)(Cat. No. SI0-HP2E5)and negative control protein respectively , washed and analyzed with FACS (QC tested).

Protocol
SI0-H5255-BLI
Siglec-10 BLI

Loaded Human CD32a (R167), His Tag (Cat. No. CDA-H5221) on HIS1K Biosensor, can bind Human Siglec-10, Fc (L118A, G120A, E201A) Tag (Cat. No. SI0-H5255) with an affinity constant of 37.5 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol
SI0-H5255-BLI
Siglec-10 BLI

Loaded Human CD64, His Tag (Cat. No. FCA-H52H1) on HIS1K Biosensor, can bind Human Siglec-10, Fc (L118A, G120A, E201A) Tag (Cat. No. SI0-H5255) with an affinity constant of 42.1 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol

カスタマーレビュー

Synonym Name

SIGLEC10,MGC126774,PRO940,Siglec10,SLG2

Background

The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.

Clinical and Translational Updates

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
Efprezimod alfa CD24-Fc; HAS-CD24; CD24-Fc-IgG; MK-7110; MK7110 Phase 3 Clinical Oncoimmune Inc Solid tumours; Hematopoietic stem cell transplantation (HSCT); Leukemia; HIV Infections; Graft vs Host Disease; Myelodysplastic Syndromes; Coronavirus Disease 2019 (COVID-19); Precursor Cell Lymphoblastic Leukemia-Lymphoma; Dyslipidemias; Leukemia, Myeloid, Acute; Melanoma Details
EXO-CD24 Phase 2 Clinical Tel-Aviv Sourasky Medical Center, Nano24med Coronavirus Disease 2019 (COVID-19); Respiratory Distress Syndrome, Adult Details
AI-071 AI-071 Phase 1 Clinical Oncoimmune-Guangzhou Neoplasms; Coronavirus Disease 2019 (COVID-19) Details
ONC-841 ONC-841 Phase 1 Clinical Oncoimmune-Guangzhou Solid tumours; Neoplasms Details
Efprezimod alfa CD24-Fc; HAS-CD24; CD24-Fc-IgG; MK-7110; MK7110 Phase 3 Clinical Oncoimmune Inc Solid tumours; Hematopoietic stem cell transplantation (HSCT); Leukemia; HIV Infections; Graft vs Host Disease; Myelodysplastic Syndromes; Coronavirus Disease 2019 (COVID-19); Precursor Cell Lymphoblastic Leukemia-Lymphoma; Dyslipidemias; Leukemia, Myeloid, Acute; Melanoma Details
EXO-CD24 Phase 2 Clinical Tel-Aviv Sourasky Medical Center, Nano24med Coronavirus Disease 2019 (COVID-19); Respiratory Distress Syndrome, Adult Details
AI-071 AI-071 Phase 1 Clinical Oncoimmune-Guangzhou Neoplasms; Coronavirus Disease 2019 (COVID-19) Details
ONC-841 ONC-841 Phase 1 Clinical Oncoimmune-Guangzhou Solid tumours; Neoplasms Details

This web search service is supported by Google Inc.

totopphone
Call us
お問い合わせ
グローバル：+1 800-810-0816(Toll Free)
日本：+(0)81-50-547-99099
Email
メールアドレス
order.jp@acrobiosystems.com
Fax
ファックス
+1 888-377-6111
Address
株式会社アクロバイオシステムズ
〒157-0066
東京都世田谷区成城1丁目26番9-101号

アクロバイオシステムズの公式アカウント

linkedin twitter facebook youtube

お問い合わせ（半角英文字で入力してください）

Copyright © 2017 ACROBiosystems. All Rights Reserved
Related Links|Privacy Policy|Terms and Conditions|Legal|Sitemap