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Your Position: ホーム > IL-1 Rrp2

IL-1 Rrp2

概要

Name:Interleukin-36 receptor
Target Synonym:Interleukin-1 Receptor-Related Protein 2,Interleukin-1 Receptor-Like 2,IL-1Rrp2,Interleukin 1 Receptor Like 2,EC:3.2.2.6,IL-36R,IL1RRP2,IL-36 Receptor,IL1R-Rp2,IL1RL2,IL-1 Receptor-Related Protein 2
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Approved

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製造番号 種類 製品説明 構造 純度 特徴
IL2-H82E9 Human Biotinylated Human IL-1 Rrp2 / IL-1 R6 Protein, His,Avitag™
IL2-H82E9-structure
IL2-H82E9-sds
IL2-H52H4 Human Human IL-1 Rrp2 / IL-1 R6 (C154S, C262S) Protein, His Tag (MALS verified)
IL2-H52H4-structure
IL2-H52H4-sds
IL2-C52H5 Cynomolgus Cynomolgus IL-1 Rrp2 / IL-1 R6 Protein, His Tag
IL2-C52H5-structure
IL2-C52H5-sds
IL2-H5254 Human Human IL-1 Rrp2 / IL-1 R6 Protein, Fc Tag
IL2-H5254-structure
IL2-H5254-sds
IL2-H52H6 Human Human IL-1 Rrp2 / IL-1 R6 Protein, His Tag
IL2-H52H6-structure
IL2-H52H6-sds
ACRO Quality

生物活性データの一部

IL2-H52H4-ELISA
IL-1 Rrp2 ELISA

Immobilized Anti-IL36R Antibody, Human IgG1 at 1 μg/mL (100 μL/well) can bind Human IL-1 Rrp2 (C154S, C262S) Protein, His Tag (Cat. No. IL2-H52H4) with a linear range of 4-125 ng/mL (QC tested).

Protocol
IL2-H52H4-MALS-HPLC
IL-1 Rrp2 MALS images

The purity of Human IL-1 Rrp2 (C154S, C262S) Protein, His Tag (Cat. No. IL2-H52H4) is more than 90% and the molecular weight of this protein is around 50-65 kDa verified by SEC-MALS.

Synonym Name

IL-1 R6,IL-1 Rrp2,IL1RL2,IL-1RL2,IL1Rrp2,IL-1Rrp2,IL1RRP2,IL-36R

Background

The Interleukin 1 receptor family (IL-1 R) comprises at least eleven members including IL-1 RI (IL-1 R1), IL-1 RII (IL-1 R2), IL-1 RAcP (IL‑1 R3), ST2 (T1/IL-1 R4), IL-18 Ra (IL-1 Rrp/IL-1 R5), IL-1 Rrp2 (IL-1 RL2/IL-1 R6), IL-18 Rb (AcPL/IL-1 R7), IL-1RAPL‑1 (TIGIRR‑2/IL‑1 R8), and TIGIRR-1 (IL-1 R9).  All family members possess three immunoglobulin (Ig)-like domains in their extracellular region. Most members also have an intracellular TIR (Toll-like receptor/IL-1 receptor signaling) domain that is also conserved in the Toll-like receptor family. Related proteins, SIGIRR (single Ig domain-containing IL-1 R-related molecule) and IL-18BP, differ from the other members by having only one Ig domain.

Clinical and Translational Updates

公開薬物情報

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Spesolimab BI-655130 Approved C.H. Boehringer Sohn Ag & Co. Kg 圣利卓, Spevigo United States Psoriasis Boehringer Ingelheim Pharmaceuticals Inc 2022-09-01 Netherton Syndrome; Psoriasis; Colitis, Ulcerative; Hidradenitis Suppurativa; Dermatitis, Atopic; Crohn Disease Details

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
IMG-008 IMG008 Phase 1 Clinical Inmagene Biopharmaceuticals Ltd Autoimmune Diseases; Inflammation Details
Imsidolimab ANB-019 Phase 3 Clinical Anaptysbio Inc Acne Vulgaris; Ichthyosis; Psoriasis; Acneiform Eruptions; Hidradenitis Suppurativa Details
HB-0034 HB-0034 Phase 1 Clinical Shanghai Huaota Biopharmaceutical Co Ltd Psoriasis Details

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