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Your Position: ホーム > CEACAM-5

CEACAM-5

概要

Name:Carcinoembryonic antigen related cell adhesion molecule 5
Target Synonym:CEA Cell Adhesion Molecule 5,CEACAM5,Meconium antigen 100,CEA,Carcinoembryonic Antigen Related Cell Adhesion Molecule 5,Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5,Carcinoembryonic Antigen,CD66e Antigen,CD66e
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:10
Lastest Research Phase:Phase 3 Clinical

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製造番号 種類 製品説明 構造 純度 特徴
CE5-H82E3 Human Biotinylated Human CEACAM-5 / CD66e (499-685) Protein, His,Avitag™ (MALS verified)
CE5-H82E3-structure
CE5-H82E3-sds
MBS-C014 Human ActiveMax® Human CEACAM-5 / CD66e μBeads, premium grade (for cells)
SCCHO-ATP081 Human CHO/Human CEACAM5 Stable Cell Line Development Service
CE5-H52H8 Human Human CEACAM-5 / CD66e (499-685) Protein, His Tag (MALS verified)
CE5-H52H8-structure
CHEK-ATP083 Human HEK293/Human CEACAM5 Stable Cell Line
CE5-C5257 Cynomolgus Cynomolgus CEACAM-5 / CD66e Protein, Llama IgG2b Fc Tag, low endotoxin (MALS verified)
CE5-C5257-structure
CE5-C5257-sds
CE5-H82E9 Human Biotinylated Human CEACAM-5 / CD66e (593-675) Protein, His,Avitag™ (HPLC verified)
CE5-H82E9-structure
CE5-H82E9-sds
CE5-H82E9-hplc
CE5-H5259 Human Human CEACAM-5 Protein, Llama IgG2b Fc Tag, low endotoxin (MALS verified)
CE5-H5259-structure
CE5-H5259-sds
CE5-C82E6 Cynomolgus Biotinylated Cynomolgus CEACAM-5 / CD66e Protein, His,Avitag™ (MALS verified)
CE5-C82E6-structure
CE5-C82E6-sds
CE5-H82F6 Human Biotinylated Human CEACAM-5 / CD66e Protein, Fc,Avitag™, premium grade
CE5-H82F6-structure
CE5-H82F6-sds
CE5-HF255 Human FITC-Labeled Human CEACAM-5 / CD66e Protein, Fc Tag
CE5-HF255-structure
CE5-HF255-sds
CE5-C52H5 Cynomolgus Cynomolgus CEACAM-5 / CD66e Protein, His Tag (MALS verified)
CE5-C52H5-structure
CE5-C52H5-sds
CE5-H5253 Human Human CEACAM-5 Protein, Fc Tag (HPLC verified)
CE5-H5253-structure
CE5-H5253-sds
CE5-H5253-hplc
CE5-M52H3 Mouse Mouse CEACAM-5 Protein, His Tag
CE5-M52H3-structure
CE5-M52H3-sds
CE5-M5253 Mouse Mouse CEACAM-5 Protein, Fc Tag
CE5-M5253-structure
CE5-M5253-sds
CE5-HF254 Human FITC-Labeled Human CEACAM-5 / CD66e Protein, His Tag (MALS verified)
CE5-HF254-structure
CE5-HF254-sds
CE5-H82E0 Human Biotinylated Human CEACAM-5 / CD66e Protein, His,Avitag™ (MALS verified)
CE5-H82E0-structure
CE5-H82E0-sds
CE5-H5226 Human Human CEACAM-5 / CD66e Protein, His Tag (MALS verified)
CE5-H5226-structure
CE5-H5226-sds
ACRO Quality

生物活性データの一部

CHEK-ATP083-Cell-based assay
CEACAM-5 FACS

Expression analysis of human CEACAM5 on HEK293/Human CEACAM5 Stable Cell Line by FACS.
Cell surface staining was performed on HEK293/Human CEACAM5 Stable Cell Line or negative control cell using PE-labeled anti-human CEACAM5 antibody.

Protocol
CE5-H82E0-SPR
CEACAM-5 SPR

Anti-CEACAM-5 (labetuzumab) Antibody, Human IgG1 captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Biotinylated Human CEACAM-5, His,Avitag (Cat. No. CE5-H82E0) with an affinity constant of 12.1 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol
CE5-H5226-SPR
CEACAM-5 SPR

Anti-CEACAM-5 (labetuzumab) Antibody, Human IgG1 captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human CEACAM-5, His Tag (Cat. No. CE5-H5226) with an affinity constant of 8.41 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol

Synonym Name

CEACAM-5,CD66e,CEA,Meconium antigen 100

Background

Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) is also Carcinoembryonic antigen (CEA), Meconium antigen 100, CD antigen CD66e, CEACAM5 belongs to the immunoglobulin superfamily and CEA family. CEACAM5 contains seven Ig-like (immunoglobulin-like) domains. CEACAM5 is homodimer protein which binding of E.coli Dr adhesins leads to dissociation of the homodimer. CEACAM5 is cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. CEACAM5 is receptor for E.coli Dr adhesins.

Clinical and Translational Updates

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
M-9140 M-9140; M9140 Phase 1 Clinical Merck KGaA, Darmstadt, Germany Solid tumours; Colorectal Neoplasms Details
Anti-CEA CAR T cell therapy (Shanghai GeneChem) Phase 2 Clinical Shanghai Genechem Co Ltd, The First Affiliated Hospital of Air Force Medical University Liver Neoplasms; Colorectal Neoplasms Details
EBC-129 EBC-129; EBC129 Phase 1 Clinical Experimental Drug Development Centre Solid tumours Details
MFE-23-CD3z T cell therapy (Cancer Research Technology) Phase 1 Clinical Cancer Research Technology Neoplasms Details
Tusamitamab Ravtansine SAR-408701; IBI-126 Phase 3 Clinical Immunogen Inc Stomach Neoplasms; Esophageal Neoplasms; Pancreatic Neoplasms; Neoplasms; Breast Neoplasms; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma Details
NEO-201 NEO-201 Phase 2 Clinical Precision Biologics Inc, National Cancer Institute Squamous Cell Carcinoma of Head and Neck; Uterine Neoplasms; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms Details
Cancer vaccine (BN ImmunoTherapeutics/National Cancer Institute) CVAC-301; CV-301 Phase 2 Clinical Therion Biologics Ovarian Neoplasms; Cystadenocarcinoma; Intestinal Neoplasms; Solid tumours; Pancreatic Neoplasms; Urinary Bladder Neoplasms; Breast Neoplasms; Prostatic Neoplasms; Colorectal Neoplasms; Carcinoma, Squamous Cell; Carcinoma, Pancreatic Ductal; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma; Neoplasm Metastasis; Melanoma Details
SGM-101 SGM-101 Phase 3 Clinical Surgimab Sas Intestinal Neoplasms; Rectal Neoplasms; Gastrointestinal Diseases; Colonic Neoplasms; Pancreatic Neoplasms; Brain Diseases; Brain Neoplasms; Colorectal Neoplasms; Brain metastases; Gastrointestinal Neoplasms; Intestinal Diseases Details
LM-24C5 LM-24C5 Phase 2 Clinical LaNova Medicines Ltd Solid tumours; Neoplasms Details
HBM-1053 HBM-1053 Harbour Biomed Details
Cergutuzumab amunaleukin RG-7813; RO-6895882 Phase 1 Clinical F. Hoffmann-La Roche Ltd Solid tumours; Neoplasms Details

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