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Your Position: ホーム > B7-H3 (4Ig)

B7-H3 (4Ig)

概要

Name:CD276 antigen
Target Synonym:B7 homolog 3,PSEC0249,UNQ309/PRO352,B7-H3,CD276 antigen,B7H3,CD276,CD276 Molecule,Costimulatory Molecule,4Ig-B7-H3,B7RP-2
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:39
Lastest Research Phase:NDA/BLA

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製造番号 種類 製品説明 構造 純度 特徴
SCCHO-ATP169 Human CHO/Human B7-H3 (4Ig) Stable Cell Line Development Service
B7B-HP2H9 Human PE-Labeled Human B7-H3 (4Ig) / B7-H3b Protein, His Tag (Site-specific conjugation)
B7B-HP2H9-structure
B7B-HF2F4 Human FITC-Labeled Human B7-H3 (4Ig) / B7-H3b Protein, Fc Tag
B7B-HF2F4-structure
B7B-HF2F4-sds
B7B-HF2E7 Human FITC-Labeled Human B7-H3 (4Ig) / B7-H3b Protein, His Tag (MALS verified)
B7B-HF2E7-structure
B7B-HF2E7-sds
B73-C52Ha Cynomolgus Cynomolgus B7-H3 (4Ig) / CD276 Protein, His Tag (MALS verified)
B73-C52Ha-structure
B73-C52Ha-sds
B7B-H82F5 Human Biotinylated Human B7-H3 (4Ig) / B7-H3b Protein, Fc,Avitag™ (MALS verified)
B7B-H82F5-structure
B7B-H82F5-sds
B7B-H82E8 Human Biotinylated Human B7-H3 (4Ig) / B7-H3b Protein, His,Avitag™ (MALS verified)
B7B-H82E8-structure
B7B-H82E8-sds
B7B-H5258 Human Human B7-H3 (4Ig) / B7-H3b Protein, Fc Tag
B7B-H5258-structure
B7B-H5258-sds
B7B-H52E7 Human Human B7-H3 (4Ig) / B7-H3b Protein, His Tag (MALS verified)
B7B-H52E7-structure
B7B-H52E7-sds
ACRO Quality

生物活性データの一部

SCCHO-ATP169-Cell-based assay
B7-H3 (4Ig) FACS

Expression analysis of human B7-H3 (4Ig) on CHO/Human B7-H3 (4Ig) Stable Cell Line by FACS.
Cell surface staining was performed on CHO/Human B7-H3 (4Ig) Stable Cell Line or negative control cell using PE-labeled anti-human B7-H3 (4Ig) antibody.

Protocol
B7B-HP2H9-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

5e5 of anti-B7-H3 CAR-293 cells were stained with 100 μL of 1:50 dilution (2 μL stock solution in 100 μL FACS buffer) of PE-Labeled Human B7-H3 (4Ig), His Tag (Cat. No. B7B-HP2H9) and negative control protein respectively. PE signal was used to evaluate the binding activity (QC tested).

Protocol
B7B-H52E7-BLI
B7-H3 (4Ig) BLI

Loaded Monoclonal Anti-Human B7-H3 / B7-H3 (4Ig) Antibody, Human IgG1 on Protein A Biosensor, can bind Human B7-H3 (4Ig), His Tag (Cat. No. B7B-H52E7) with an affinity constant of 1.74 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol
B7B-HF2E7-ELISA
B7-H3 (4Ig) ELISA

Immobilized Monoclonal Anti-Human B7-H3 / B7-H3 (4Ig) Antibody, Human IgG1 at 2 μg/mL (100 μL/well) can bind FITC-Labeled Human B7-H3 (4Ig), His Tag (Cat. No. B7B-HF2E7) with a linear range of 0.039-0.156 μg/mL (QC tested).

Protocol

Synonym Name

4Ig-B7-H3,B7-H3,CD276,PSEC0249,UNQ309,PRO352,B7 homolog 3

Background

Human B7 homolog 3 (B7-H3) is a member of the B7 family of immune proteins that provide signals for the regulation of immune responses. Other family members include B7-1, B7-2, B7-H1/PD-L1, B7-H2, and PD-L2. B7 family proteins are type I transmembrane immunoglobulin (Ig) superfamily members that contain extracellular Ig V‑like and Ig C‑like domains with a short cytoplasmic tail. Termed 4IgB7-H3 or B7-H3b, this molecule has two additional Ig-like domains (one V‑type and one C‑type) and shows a ubiquituous expression pattern.

Clinical and Translational Updates

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
Ifinatamab deruxtecan DS-7300; DS-7300a; MABX-9001a Phase 3 Clinical Daiichi Sankyo Co Ltd Solid tumours; Small Cell Lung Carcinoma Details
B7-H3 CAR-T cell therapy (Boyuan Runsheng Pharma) Phase 2 Clinical Boyuan Runsheng Pharma (Hangzhou) Co Ltd Solid tumours; Glioblastoma Details
Obrindatamab MGD-009; B7-H3 x CD3 Phase 2 Clinical Macrogenics Inc Mesothelioma; Carcinoma, Non-Small-Cell Lung; Melanoma; Thyroid Neoplasms; Sarcoma; Neuroblastoma; Neurofibrosarcoma; Prostatic Neoplasms; Breast Neoplasms; Ovarian Neoplasms; Sarcoma, Synovial; Urinary Bladder Neoplasms; Wilms Tumor; Pancreatic Neoplasms; Colonic Neoplasms; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Rhabdomyosarcoma Details
Vobramitamab duocarmazine MGC-018 Phase 2 Clinical Macrogenics Inc Liver Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Anus Neoplasms; Carcinoma, Renal Cell; Small Cell Lung Carcinoma; Carcinoma, Ovarian Epithelial; Prostatic Neoplasms, Castration-Resistant; Prostatic Neoplasms; Laryngeal Neoplasms; Carcinoma, Squamous Cell; Carcinoma, Small Cell; Carcinoma, Pancreatic Ductal; Carcinoma, Non-Small-Cell Lung; Melanoma Details
TAK-280 MVC-280; TAK-280 Phase 2 Clinical Maverick Therapeutics Inc Solid tumours; Neoplasms; Neoplasm Metastasis Details
4SCAR-276 4SCAR-276 Phase 2 Clinical Shenzhen Geno-Immune Medical Institute Solid tumours Details
IBI-3001 IBI-3001; IBI3001 Phase 2 Clinical Innovent Biologics(Suzhou) Co Ltd Solid tumours Details
Allogenic B7H3-targeting CAR-γδT Cell Therapy QH104 Cell; QH-104 Cell Phase 2 Clinical Suzhou Dushu Lake Hospital (Dushu Lake Hospital Affiliated To Soochow University) Glioblastoma Details
IBI129 IBI-129; IBI129 Phase 2 Clinical Innovent Biologics(Suzhou) Co Ltd Solid tumours Details
7MW3711 7-MW-3711; 7MW3711 Phase 2 Clinical Mabwell (Shanghai) Bioscience Co Ltd Solid tumours; Neoplasms Details
IBI334 IBI334; IBI-334 Phase 2 Clinical Innovent Biologics(Suzhou) Co Ltd Solid tumours; Neoplasms Details
MHB088C MHB-088C Phase 2 Clinical Minghui Pharmaceutical Pty Ltd Solid tumours Details
DB-1311 DB-1311 Phase 2 Clinical Solid tumours; Neoplasm Metastasis Details
IBB-0979 IBB0979; IBB-0979 Phase 2 Clinical SunHo (China) BioPharmaceutical Co Ltd Solid tumours; Neoplasms Details
YL-201 YL-201; YL201 Phase 2 Clinical MediLink Therapeutics Co Ltd Solid tumours; Prostatic Neoplasms, Castration-Resistant Details
Fully Human B7H3 CAR-T Cells Therapy fhB7H3.CAR-Ts Phase 2 Clinical The Affiliated Hospital Of Xuzhou Medical University Ovarian Neoplasms; Carcinoma, Hepatocellular Details
CD-276-targeted Chimeric Antigen Receptor T Cell Therapy CD276 CAR-T Phase 2 Clinical Shenzhen University General Hospital Pancreatic Neoplasms Details
Enoblituzumab MGA-271; TJ271 Phase 2 Clinical Macrogenics Inc Carcinoma, Transitional Cell; Melanoma; Carcinoma, Non-Small-Cell Lung; Fallopian Tube Neoplasms; Peritoneal Neoplasms; Osteosarcoma; Neuroblastoma; Sarcoma, Ewing; Prostatic Neoplasms; Urethral Neoplasms; Urinary Bladder Neoplasms; Ovarian Neoplasms; Neoplasms; Triple Negative Breast Neoplasms; Wilms Tumor; Carcinoma, Renal Cell; Desmoplastic Small Round Cell Tumor; Abdominal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Solid tumours; Rhabdomyosarcoma; Head and Neck Neoplasms Details
HS-20093 HS20093; HS-20093 Phase 2 Clinical Shanghai Hansoh Biomedical Co Ltd Solid tumours; Squamous Cell Carcinoma of Head and Neck; Esophageal Neoplasms; Small Cell Lung Carcinoma; Prostatic Neoplasms, Castration-Resistant; Sarcoma; Osteosarcoma Details
124I-omburtamab 124I-8H9; 124I-8H9-(B7-H3) Phase 1 Clinical Memorial Sloan Kettering Cancer Center, Y-Mabs Therapeutics Inc Brain Neoplasms; Glioma Details
Mirzotamab clezutoclax ABBV-155 Phase 1 Clinical Abbvie Inc Solid tumours Details
SCRI-CARB7H3 SCRI-CARB7H3 Phase 1 Clinical Seattle Children'S Hospital Neuroblastoma; Choroid Plexus Neoplasms; Neoplasms, Germ Cell and Embryonal; Melanoma; Glioma; Diffuse Intrinsic Pontine Glioma; Neuroectodermal Tumors, Primitive; Sarcoma; Sarcoma, Clear Cell; Neurofibrosarcoma; Sarcoma, Ewing; Osteosarcoma; Retinoblastoma; Teratoma; Sarcoma, Synovial; Central Nervous System Neoplasms; Wilms Tumor; Diffuse midline glioma; Hepatoblastoma; Rhabdoid Tumor; Desmoplastic Small Round Cell Tumor; Carcinoma; Rhabdomyosarcoma; Medulloblastoma; Solid tumours; Ependymoma Details
CC-3 CC-3 Phase 1 Clinical Eberhard Karls University Of Tubingen, Germany Colorectal Neoplasms; Gastrointestinal Neoplasms Details
KT-095 KT-095 Phase 1 Clinical Nanjing Kati Medical Technology Co Ltd Solid tumours Details
EX-105 EX-105; EX105 Phase 1 Clinical Guangzhou Excelmab Inc Solid tumours Details
MGC-026 MGC026; MGC-026 Phase 1 Clinical Macrogenics Inc Prostatic Neoplasms, Castration-Resistant; Uterine Cervical Neoplasms; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Melanoma; Endometrial Neoplasms; Colorectal Neoplasms; Sarcoma; Urinary Bladder Neoplasms; Ovarian Neoplasms; Neoplasms; Small Cell Lung Carcinoma; Pancreatic Neoplasms; Stomach Neoplasms; Esophageal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Solid tumours Details
Loco-regional B7H3 IL-7Ra CAR T Cell therapy(Chulalongkorn University) Phase 1 Clinical Chulalongkorn University, King Chulalongkorn Memorial Hospital Brain Neoplasms; Diffuse Intrinsic Pontine Glioma Details
Autologous CAR-T Cells Targeting B7-H3(Unc Lineberger Comprehensive Cancer Center) Phase 1 Clinical Unc Lineberger Comprehensive Cancer Center Ovarian Neoplasms; Pancreatic Neoplasms; Carcinoma, Ovarian Epithelial; Triple Negative Breast Neoplasms; Neoplasms; Breast Neoplasms Details
MT-027 MT-027 Phase 1 Clinical T-Maximum Pharmaceutical (Suzhou) Co Ltd Glioma Details
UTAA06 UTAA-06 Phase 1 Clinical Persongen Biotherapeutics (Suzhou) Co Ltd Leukemia, Myeloid, Acute Details
B7-H3 CAR T-cell therapy(Stanford University) B7-H3CART Phase 1 Clinical Stanford University Nervous System Diseases Details
TX103 CAR-T cell therapy(Fuzhou Tuoxin Tiancheng Biotechnology) Phase 1 Clinical Fuzhou Tuoxin Tiancheng Biotechnology Co Ltd Solid tumours; Glioma Details
EGFR/B7H3 CAR-T EGFR/B7H3 CAR-T Phase 1 Clinical Second Affiliated Hospital Of Guangzhou Medical University Triple Negative Breast Neoplasms; Lung Neoplasms Details
BAT-8009 BAT8009; BAT-8009 Phase 1 Clinical Bio-Thera Solutions Ltd Solid tumours Details
TAA-06 TAA06-UCAR-γδT; TAA-06 Phase 1 Clinical Persongen Biotherapeutics (Suzhou) Co Ltd Solid tumours; Neuroblastoma; Colorectal Neoplasms; Lung Neoplasms; Melanoma Details
XmAb-808 XmAb808 Phase 1 Clinical Xencor Inc Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Transitional Cell; Carcinoma, Ovarian Epithelial; Triple Negative Breast Neoplasms; Prostatic Neoplasms, Castration-Resistant; Colorectal Neoplasms; Melanoma; Carcinoma, Non-Small-Cell Lung Details
Anti-CD276 CAR T-cell therapy (Persongen ) Phase 1 Clinical Persongen Biotherapeutics (Suzhou) Co Ltd Stomach Neoplasms; Small Cell Lung Carcinoma; Osteosarcoma; Neuroblastoma; Lung Neoplasms Details
B7-H3-targeting CAR-T cell therapy Beijing Tiantan Hospital, Capital Medical University Details
Ifinatamab deruxtecan DS-7300; DS-7300a; MABX-9001a Phase 3 Clinical Daiichi Sankyo Co Ltd Solid tumours; Small Cell Lung Carcinoma Details
B7-H3 CAR-T cell therapy (Boyuan Runsheng Pharma) Phase 2 Clinical Boyuan Runsheng Pharma (Hangzhou) Co Ltd Solid tumours; Glioblastoma Details
Obrindatamab MGD-009; B7-H3 x CD3 Phase 2 Clinical Macrogenics Inc Mesothelioma; Carcinoma, Non-Small-Cell Lung; Melanoma; Thyroid Neoplasms; Sarcoma; Neuroblastoma; Neurofibrosarcoma; Prostatic Neoplasms; Breast Neoplasms; Ovarian Neoplasms; Sarcoma, Synovial; Urinary Bladder Neoplasms; Wilms Tumor; Pancreatic Neoplasms; Colonic Neoplasms; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Rhabdomyosarcoma Details
Vobramitamab duocarmazine MGC-018 Phase 2 Clinical Macrogenics Inc Liver Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Anus Neoplasms; Carcinoma, Renal Cell; Small Cell Lung Carcinoma; Carcinoma, Ovarian Epithelial; Prostatic Neoplasms, Castration-Resistant; Prostatic Neoplasms; Laryngeal Neoplasms; Carcinoma, Squamous Cell; Carcinoma, Small Cell; Carcinoma, Pancreatic Ductal; Carcinoma, Non-Small-Cell Lung; Melanoma Details
TAK-280 MVC-280; TAK-280 Phase 2 Clinical Maverick Therapeutics Inc Solid tumours; Neoplasms; Neoplasm Metastasis Details
4SCAR-276 4SCAR-276 Phase 2 Clinical Shenzhen Geno-Immune Medical Institute Solid tumours Details
IBI-3001 IBI-3001; IBI3001 Phase 2 Clinical Innovent Biologics(Suzhou) Co Ltd Solid tumours Details
Allogenic B7H3-targeting CAR-γδT Cell Therapy QH104 Cell; QH-104 Cell Phase 2 Clinical Suzhou Dushu Lake Hospital (Dushu Lake Hospital Affiliated To Soochow University) Glioblastoma Details
IBI129 IBI-129; IBI129 Phase 2 Clinical Innovent Biologics(Suzhou) Co Ltd Solid tumours Details
7MW3711 7-MW-3711; 7MW3711 Phase 2 Clinical Mabwell (Shanghai) Bioscience Co Ltd Solid tumours; Neoplasms Details
IBI334 IBI334; IBI-334 Phase 2 Clinical Innovent Biologics(Suzhou) Co Ltd Solid tumours; Neoplasms Details
MHB088C MHB-088C Phase 2 Clinical Minghui Pharmaceutical Pty Ltd Solid tumours Details
DB-1311 DB-1311 Phase 2 Clinical Solid tumours; Neoplasm Metastasis Details
IBB-0979 IBB0979; IBB-0979 Phase 2 Clinical SunHo (China) BioPharmaceutical Co Ltd Solid tumours; Neoplasms Details
YL-201 YL-201; YL201 Phase 2 Clinical MediLink Therapeutics Co Ltd Solid tumours; Prostatic Neoplasms, Castration-Resistant Details
Fully Human B7H3 CAR-T Cells Therapy fhB7H3.CAR-Ts Phase 2 Clinical The Affiliated Hospital Of Xuzhou Medical University Ovarian Neoplasms; Carcinoma, Hepatocellular Details
CD-276-targeted Chimeric Antigen Receptor T Cell Therapy CD276 CAR-T Phase 2 Clinical Shenzhen University General Hospital Pancreatic Neoplasms Details
Enoblituzumab MGA-271; TJ271 Phase 2 Clinical Macrogenics Inc Carcinoma, Transitional Cell; Melanoma; Carcinoma, Non-Small-Cell Lung; Fallopian Tube Neoplasms; Peritoneal Neoplasms; Osteosarcoma; Neuroblastoma; Sarcoma, Ewing; Prostatic Neoplasms; Urethral Neoplasms; Urinary Bladder Neoplasms; Ovarian Neoplasms; Neoplasms; Triple Negative Breast Neoplasms; Wilms Tumor; Carcinoma, Renal Cell; Desmoplastic Small Round Cell Tumor; Abdominal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Solid tumours; Rhabdomyosarcoma; Head and Neck Neoplasms Details
HS-20093 HS20093; HS-20093 Phase 2 Clinical Shanghai Hansoh Biomedical Co Ltd Solid tumours; Squamous Cell Carcinoma of Head and Neck; Esophageal Neoplasms; Small Cell Lung Carcinoma; Prostatic Neoplasms, Castration-Resistant; Sarcoma; Osteosarcoma Details
124I-omburtamab 124I-8H9; 124I-8H9-(B7-H3) Phase 1 Clinical Memorial Sloan Kettering Cancer Center, Y-Mabs Therapeutics Inc Brain Neoplasms; Glioma Details
Mirzotamab clezutoclax ABBV-155 Phase 1 Clinical Abbvie Inc Solid tumours Details
SCRI-CARB7H3 SCRI-CARB7H3 Phase 1 Clinical Seattle Children'S Hospital Neuroblastoma; Choroid Plexus Neoplasms; Neoplasms, Germ Cell and Embryonal; Melanoma; Glioma; Diffuse Intrinsic Pontine Glioma; Neuroectodermal Tumors, Primitive; Sarcoma; Sarcoma, Clear Cell; Neurofibrosarcoma; Sarcoma, Ewing; Osteosarcoma; Retinoblastoma; Teratoma; Sarcoma, Synovial; Central Nervous System Neoplasms; Wilms Tumor; Diffuse midline glioma; Hepatoblastoma; Rhabdoid Tumor; Desmoplastic Small Round Cell Tumor; Carcinoma; Rhabdomyosarcoma; Medulloblastoma; Solid tumours; Ependymoma Details
CC-3 CC-3 Phase 1 Clinical Eberhard Karls University Of Tubingen, Germany Colorectal Neoplasms; Gastrointestinal Neoplasms Details
KT-095 KT-095 Phase 1 Clinical Nanjing Kati Medical Technology Co Ltd Solid tumours Details
EX-105 EX-105; EX105 Phase 1 Clinical Guangzhou Excelmab Inc Solid tumours Details
MGC-026 MGC026; MGC-026 Phase 1 Clinical Macrogenics Inc Prostatic Neoplasms, Castration-Resistant; Uterine Cervical Neoplasms; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Melanoma; Endometrial Neoplasms; Colorectal Neoplasms; Sarcoma; Urinary Bladder Neoplasms; Ovarian Neoplasms; Neoplasms; Small Cell Lung Carcinoma; Pancreatic Neoplasms; Stomach Neoplasms; Esophageal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Solid tumours Details
Loco-regional B7H3 IL-7Ra CAR T Cell therapy(Chulalongkorn University) Phase 1 Clinical Chulalongkorn University, King Chulalongkorn Memorial Hospital Brain Neoplasms; Diffuse Intrinsic Pontine Glioma Details
Autologous CAR-T Cells Targeting B7-H3(Unc Lineberger Comprehensive Cancer Center) Phase 1 Clinical Unc Lineberger Comprehensive Cancer Center Ovarian Neoplasms; Pancreatic Neoplasms; Carcinoma, Ovarian Epithelial; Triple Negative Breast Neoplasms; Neoplasms; Breast Neoplasms Details
MT-027 MT-027 Phase 1 Clinical T-Maximum Pharmaceutical (Suzhou) Co Ltd Glioma Details
UTAA06 UTAA-06 Phase 1 Clinical Persongen Biotherapeutics (Suzhou) Co Ltd Leukemia, Myeloid, Acute Details
B7-H3 CAR T-cell therapy(Stanford University) B7-H3CART Phase 1 Clinical Stanford University Nervous System Diseases Details
TX103 CAR-T cell therapy(Fuzhou Tuoxin Tiancheng Biotechnology) Phase 1 Clinical Fuzhou Tuoxin Tiancheng Biotechnology Co Ltd Solid tumours; Glioma Details
EGFR/B7H3 CAR-T EGFR/B7H3 CAR-T Phase 1 Clinical Second Affiliated Hospital Of Guangzhou Medical University Triple Negative Breast Neoplasms; Lung Neoplasms Details
BAT-8009 BAT8009; BAT-8009 Phase 1 Clinical Bio-Thera Solutions Ltd Solid tumours Details
TAA-06 TAA06-UCAR-γδT; TAA-06 Phase 1 Clinical Persongen Biotherapeutics (Suzhou) Co Ltd Solid tumours; Neuroblastoma; Colorectal Neoplasms; Lung Neoplasms; Melanoma Details
XmAb-808 XmAb808 Phase 1 Clinical Xencor Inc Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Transitional Cell; Carcinoma, Ovarian Epithelial; Triple Negative Breast Neoplasms; Prostatic Neoplasms, Castration-Resistant; Colorectal Neoplasms; Melanoma; Carcinoma, Non-Small-Cell Lung Details
Anti-CD276 CAR T-cell therapy (Persongen ) Phase 1 Clinical Persongen Biotherapeutics (Suzhou) Co Ltd Stomach Neoplasms; Small Cell Lung Carcinoma; Osteosarcoma; Neuroblastoma; Lung Neoplasms Details
B7-H3-targeting CAR-T cell therapy Beijing Tiantan Hospital, Capital Medical University Details

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