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Your Position: ホーム > PSCA

PSCA

概要

Name:Prostate stem cell antigen
Target Synonym:Prostate stem cell antigen,UNQ206/PRO232,PSCA,PRO232
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 1 Clinical

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製造番号 種類 製品説明 構造 純度 特徴
PSA-M82Ea Mouse Biotinylated Mouse PSCA Protein, His,Avitag™, low endotoxin (MALS verified)
PSA-M82Ea-structure
PSA-M82E3 Mouse Biotinylated Mouse PSCA Protein, His,Avitag™ (MALS verified)
PSA-M82E3-structure
PSA-M82E3-sds
PSA-H82E3 Human Biotinylated Human PSCA Protein, His,Avitag™ (MALS verified)
PSA-H82E3-structure
PSA-H82E3-sds
PSA-H52H6 Human Human PSCA Protein, His Tag
PSA-H52H6-structure
PSA-H52H6-sds
ACRO Quality

生物活性データの一部

PSA-H82E3-Cell-based assay
PSCA FACS

2e5 of anti-PSCA CAR-293 cells were stained with 100 μL of 3 μg/mL of Biotinylated Human PSCA, His,Avitag (Cat. No. PSA-H82E3) and negative control protein respectively, washed and then followed by PE-SA antibody and analyzed with FACS (Routinely tested).

Protocol
PSA-H52H6-Cell-based assay
PSCA FACS

2e5 of anti-PSCA CAR-293 cells were stained with 100 μL of 3 μg/mL of Human PSCA, His Tag (Cat. No. PSA-H52H6) and negative control protein respectively, washed and then followed by PE anti-His Tag antibody and analyzed with FACS (Routinely tested).

Protocol
PSA-H52H6-ELISA
PSCA ELISA

Immobilized Human PSCA, His Tag (Cat. No. PSA-H52H6) at 1 μg/mL (100 μL/well) can bind Anti-PSCA Antibody,Human IgG1 with a linear range of 0.2-1 ng/mL (QC tested).

Protocol
PSA-M82Ea-MALS-HPLC
PSCA MALS images

The purity of Biotinylated Mouse PSCA, His,Avitag (Cat. No. PSA-M82Ea) is more than 95% and the molecular weight of this protein is around 18-26 kDa verified by SEC-MALS.

Synonym Name

PSCA,UNQ206,PRO232

Background

The Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol (GPI)-anchored protein, plays an important role in tumorigenesis. The prostate stem cell antigen (PSCA) gene, which encodes a prostate-specific antigen (PSA), was identified as a gene involved in cell adhesion and proliferation. PSCA may be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro. May act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs.

Clinical and Translational Updates

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
Autologous Anti-PSCA-CAR-4-1BB/TCRzeta-CD19t-expressing T-lymphocytes (City of Hope Medical Center) Phase 1 Clinical City Of Hope National Medical Center Prostatic Neoplasms, Castration-Resistant; Prostatic Neoplasms Details
124-iodine-labeled PSCA targeting minibody (ImaginAb) Phase 1 Clinical University Of California At Los Angeles Pancreatic Neoplasms; Urinary Bladder Neoplasms; Prostatic Neoplasms Details
Autologous Anti-PSCA-CAR-4-1BB/TCRzeta-CD19t-expressing T-lymphocytes (City of Hope Medical Center) Phase 1 Clinical City Of Hope National Medical Center Prostatic Neoplasms, Castration-Resistant; Prostatic Neoplasms Details
124-iodine-labeled PSCA targeting minibody (ImaginAb) Phase 1 Clinical University Of California At Los Angeles Pancreatic Neoplasms; Urinary Bladder Neoplasms; Prostatic Neoplasms Details

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