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GAS6

概要

Name:Growth arrest-specific protein 6
Target Synonym:GAS6,AXLLG,Growth Arrest Specific 6,AXL Receptor Tyrosine Kinase Ligand,AXL Stimulatory Factor,Growth Arrest-Specific Protein 6,GAS-6,AXSF,FLJ34709,DKFZp666G247
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 3 Clinical

製品リスト製品比較と製品注文

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製造番号 種類 製品説明 構造 純度 特徴
GA6-H5246 Human Human GAS6 (49-678) Protein, His Tag
GA6-H5246-structure
GA6-H5246-sds
GA6-H5247 Human Human GAS6 (471-678) Protein, His Tag (MALS verified)
GA6-H5247-structure
GA6-H5247-sds
GA6-H5249 Human Human GAS6 (279-678) Protein, His Tag (MALS verified)
GA6-H5249-structure
GA6-H5249-sds
ACRO Quality

生物活性データの一部

GA6-H5246-SPR
 GAS6 SPR

Human Axl, Fc Tag (Cat. No. AXL-H5253) captured on Protein A Chip can bind Human GAS6 Protein, His Tag (Cat. No. GA6-H5246) with an affinity constant of 38.6 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

GA6-H5249-SPR
 GAS6 SPR

Human Axl, His Tag (Cat. No. AXL-H5226) immobilized on CM5 Chip can bind Human GAS6, His Tag (Cat. No. GA6-H5249) with an affinity constant of 3.4 nM as determined in SPR assay (Biacore 8K) (Routinely tested).

Synonym Name

GAS6,GAS-6,AXLLG

Background

GAS6 (Growth arrest-specific protein 6) is also known as AXL receptor tyrosine kinase ligand, AXLLG. Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.

Clinical and Translational Updates

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
Batiraxcept AVB-500; Aravive S-6; AVB-S6-500; Ruga-S6; 3D-229; 3D229 Phase 3 Clinical Aravive Inc Ovarian Neoplasms; Solid tumours; Glomerulonephritis, IGA; Carcinoma, Renal Cell; Neoplasms; Pancreatic Neoplasms; Carcinoma, Transitional Cell; Carcinoma, Ovarian Epithelial; Peritoneal Neoplasms; Uterine Neoplasms; Fallopian Tube Neoplasms Details

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