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Your Position: ホーム > BTLA

BTLA

概要

Name:B- and T-lymphocyte attenuator
Target Synonym:BTLA,B- and T-lymphocyte attenuator,B- and T-lymphocyte-associated protein,B And T Lymphocyte Associated,CD272 Antigen,BTLA1,CD272
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:5
Lastest Research Phase:Phase 3 Clinical

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製造番号 種類 製品説明 構造 純度 特徴
SCJUR-STF106 Human Human BTLA (Luc) Jurkat Reporter Cell Development Service
SCCHO-ATP110 Human CHO/Human BTLA Stable Cell Line Development Service
BTA-H5254 Human Human BTLA (31-150) (M105V, G138S, V148M) Protein, Fc Tag (MALS verified)
BTA-H5254-structure
BTA-H5254-sds
BTA-H82E4 Human Biotinylated Human BTLA (31-150) Protein, His,Avitag™ (MALS verified)
BTA-H82E4-structure
BTA-H82E4-sds
BTA-H82F5 Human Biotinylated Human BTLA (31-150) (M105V, G138S, V148M) Protein, Fc,Avitag™ (MALS verified)
BTA-H82F5-structure
BTA-H82F5-sds
BTA-H52H5 Human Human BTLA (31-150) (M105V, G138S, V148M) Protein, His Tag (MALS verified)
BTA-H52H5-structure
BTA-H52H5-sds
BTA-H82E5 Human Biotinylated Human BTLA (31-150) (M105V, G138S, V148M) Protein, His,Avitag™ (MALS verified)
BTA-H82E5-structure
BTA-H82E5-sds
BTA-H52H3 Human Human BTLA (31-150) Protein, His Tag (MALS verified)
BTA-H52H3-structure
BTA-H52H3-sds
BTA-H5258 Human Human BTLA (31-150) Protein, Mouse IgG2a Fc Tag (MALS verified)
BTA-H5258-structure
BTA-H5258-sds
BTA-H82F3 Human Biotinylated Human BTLA (31-150) Protein, Fc,Avitag™ (MALS verified)
BTA-H82F3-structure
BTA-H82F3-sds
BTA-H82F8 Human Biotinylated Human BTLA (31-134) Protein, Fc,Avitag™
BTA-H82F8-structure
BTA-H82F8-sds
BTA-M5253 Mouse Mouse BTLA Protein, Fc Tag (MALS verified)
BTA-M5253-structure
BTA-M5253-sds
BTA-M52E2 Mouse Mouse BTLA Protein, His Tag
BTA-M52E2-structure
BTA-M52E2-sds
BTA-H5256 Human Human BTLA (31-150) Protein, Fc Tag (MALS verified)
BTA-H5256-structure
BTA-H5256-sds
BTA-H5255 Human Human BTLA (31-134) Protein, Fc Tag
BTA-H5255-structure
BTA-H5255-sds
ACRO Quality

生物活性データの一部

SCJUR-STF106-Cell-based assay
BTLA FACS

Expression analysis of human BTLA on Human BTLA (Luc) Jurkat Reporter Cell by FACS.
Human BTLA (Luc) Jurkat Reporter Cell or negative control cell were stained with PE-labeled anti-human BTLA antibody.

Protocol
SCCHO-ATP110-Cell-based assay
BTLA FACS

Expression analysis of human BTLA on CHO/Human BTLA Stable Cell Line by FACS.
Cell surface staining was performed on CHO/Human BTLA Stable Cell Line or negative control cell using PE-labeled anti human BTLA antibody.

Protocol
BTA-H52H3-BLI
BTLA BLI

Loaded Human BTLA (31-150), His Tag (Cat. No. BTA-H52H3) on NTA Biosensor, can Human HVEM, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. HVM-H5255) with an affinity constant of 20.8 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol
BTA-H82E4-ELISA
BTLA ELISA

Immobilized Biotinylated Human BTLA (31-150), His,Avitag (Cat. No. BTA-H82E4) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Human HVEM, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. HVM-H5255) with a linear range of 2-78 ng/mL (QC tested).

Protocol

Synonym Name

BTLA,CD272

Background

B- and T-lymphocyte attenuator (BTLA) is also known as B- and T-lymphocyte-associated protein, CD antigen CD272. BTLA contains one Ig-like V-type (immunoglobulin-like) domain. As a lymphocyte inhibitory receptor, BTLA / CD272 inhibits lymphocytes during immune response. BTLA / CD272 can interact with tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2, and interact with TNFRSF14/HVEM.

Clinical and Translational Updates

相関分子

HVEM B7-H4

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
Tifcemalimab TAB-004; JS-004 Phase 3 Clinical Shanghai Junshi Biosciences Co Ltd Solid tumours; Head and Neck Neoplasms; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Transitional Cell; Small Cell Lung Carcinoma; Pancreatic Neoplasms; Hodgkin Disease; Nasopharyngeal Carcinoma; Lymphoma; Lung Neoplasms; Melanoma; Neoplasm Metastasis Details
ANB-032 ANB-032 Phase 2 Clinical Anaptysbio Inc Inflammation; Dermatitis, Atopic; Eczema Details
Venanprubart LY-3361237 Phase 2 Clinical Sanford-Burnham Medical Research Institute, Eli Lilly And Company Sjogren's Syndrome; Lupus Erythematosus, Systemic; Psoriasis Details
MB-272 MB272; GS-0272 Phase 1 Clinical University Of Oxford, MiroBio Ltd Arthritis, Rheumatoid; Autoimmune Diseases; Lupus Erythematosus, Systemic Details
HFB-200603 HFB-200603 Phase 1 Clinical HiFiBiO Therapeutics Carcinoma, Renal Cell; Stomach Neoplasms; Neoplasms; Colorectal Neoplasms; Melanoma; Carcinoma, Non-Small-Cell Lung Details

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