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BTLA

概要

Name:B- and T-lymphocyte attenuator
Target Synonym:BTLA,B- and T-lymphocyte attenuator,B- and T-lymphocyte-associated protein,B And T Lymphocyte Associated,CD272 Antigen,BTLA1,CD272
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:5
Lastest Research Phase:Phase 3 Clinical

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製造番号 種類 製品説明 構造 純度 特徴
SCCHO-ATP110 Human CHO/Human BTLA Stable Cell Line Development Service
BTA-H5254 Human Human BTLA (31-150) (M105V, G138S, V148M) Protein, Fc Tag (MALS verified)
BTA-H5254-structure
BTA-H5254-sds
BTA-H82E4 Human Biotinylated Human BTLA (31-150) Protein, His,Avitag™ (MALS verified)
BTA-H82E4-structure
BTA-H82E4-sds
BTA-H82F5 Human Biotinylated Human BTLA (31-150) (M105V, G138S, V148M) Protein, Fc,Avitag™ (MALS verified)
BTA-H82F5-structure
BTA-H82F5-sds
BTA-H52H5 Human Human BTLA (31-150) (M105V, G138S, V148M) Protein, His Tag (MALS verified)
BTA-H52H5-structure
BTA-H52H5-sds
BTA-H82E5 Human Biotinylated Human BTLA (31-150) (M105V, G138S, V148M) Protein, His,Avitag™ (MALS verified)
BTA-H82E5-structure
BTA-H82E5-sds
BTA-H52H3 Human Human BTLA (31-150) Protein, His Tag (MALS verified)
BTA-H52H3-structure
BTA-H52H3-sds
BTA-H5258 Human Human BTLA (31-150) Protein, Mouse IgG2a Fc Tag (MALS verified)
BTA-H5258-structure
BTA-H5258-sds
BTA-H82F3 Human Biotinylated Human BTLA (31-150) Protein, Fc,Avitag™ (MALS verified)
BTA-H82F3-structure
BTA-H82F3-sds
BTA-H82F8 Human Biotinylated Human BTLA (31-134) Protein, Fc,Avitag™
BTA-H82F8-structure
BTA-H82F8-sds
BTA-M5253 Mouse Mouse BTLA Protein, Fc Tag (MALS verified)
BTA-M5253-structure
BTA-M5253-sds
BTA-M52E2 Mouse Mouse BTLA Protein, His Tag
BTA-M52E2-structure
BTA-M52E2-sds
BTA-H5256 Human Human BTLA (31-150) Protein, Fc Tag (MALS verified)
BTA-H5256-structure
BTA-H5256-sds
BTA-H5255 Human Human BTLA (31-134) Protein, Fc Tag
BTA-H5255-structure
BTA-H5255-sds
ACRO Quality

Synonym Name

BTLA,CD272

Background

B- and T-lymphocyte attenuator (BTLA) is also known as B- and T-lymphocyte-associated protein, CD antigen CD272. BTLA contains one Ig-like V-type (immunoglobulin-like) domain. As a lymphocyte inhibitory receptor, BTLA / CD272 inhibits lymphocytes during immune response. BTLA / CD272 can interact with tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2, and interact with TNFRSF14/HVEM.

Clinical and Translational Updates

相関分子

HVEM B7-H4

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
Tifcemalimab TAB-004; JS-004 Phase 3 Clinical Shanghai Junshi Biosciences Co Ltd Solid tumours; Head and Neck Neoplasms; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Transitional Cell; Small Cell Lung Carcinoma; Pancreatic Neoplasms; Hodgkin Disease; Nasopharyngeal Carcinoma; Lymphoma; Lung Neoplasms; Melanoma; Neoplasm Metastasis Details
ANB-032 ANB-032 Phase 2 Clinical Anaptysbio Inc Inflammation; Dermatitis, Atopic; Eczema Details
Venanprubart LY-3361237 Phase 2 Clinical Sanford-Burnham Medical Research Institute, Eli Lilly And Company Sjogren's Syndrome; Lupus Erythematosus, Systemic; Psoriasis Details
MB-272 MB272; GS-0272 Phase 1 Clinical University Of Oxford Arthritis, Rheumatoid; Autoimmune Diseases; Lupus Erythematosus, Systemic Details
HFB-200603 HFB-200603 Phase 1 Clinical HiFiBiO Therapeutics Carcinoma, Renal Cell; Stomach Neoplasms; Neoplasms; Colorectal Neoplasms; Melanoma; Carcinoma, Non-Small-Cell Lung Details
Tifcemalimab TAB-004; JS-004 Phase 3 Clinical Shanghai Junshi Biosciences Co Ltd Solid tumours; Head and Neck Neoplasms; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Transitional Cell; Small Cell Lung Carcinoma; Pancreatic Neoplasms; Hodgkin Disease; Nasopharyngeal Carcinoma; Lymphoma; Lung Neoplasms; Melanoma; Neoplasm Metastasis Details
ANB-032 ANB-032 Phase 2 Clinical Anaptysbio Inc Inflammation; Dermatitis, Atopic; Eczema Details
Venanprubart LY-3361237 Phase 2 Clinical Sanford-Burnham Medical Research Institute, Eli Lilly And Company Sjogren's Syndrome; Lupus Erythematosus, Systemic; Psoriasis Details
MB-272 MB272; GS-0272 Phase 1 Clinical University Of Oxford Arthritis, Rheumatoid; Autoimmune Diseases; Lupus Erythematosus, Systemic Details
HFB-200603 HFB-200603 Phase 1 Clinical HiFiBiO Therapeutics Carcinoma, Renal Cell; Stomach Neoplasms; Neoplasms; Colorectal Neoplasms; Melanoma; Carcinoma, Non-Small-Cell Lung Details

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