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Your Position: ホーム > TROP-2

TROP-2

概要

Name:Tumor-associated calcium signal transducer 2
Target Synonym:Tumor-associated calcium signal transducer 2,M1S1,TROP2,TACSTD2,Pancreatic carcinoma marker protein GA733-1,Tumor Associated Calcium Signal Transducer 2,GA733-1,Membrane Component, Chromosome 1, Surface Marker 1,Gastrointestinal Tumor-Associated Antigen GA7331,Pancreatic Carcinoma Marker Protein GA7331,Cell surface glycoprotein Trop-2,Membrane component chromosome 1 surface marker 1,40kD Glycoprotein, Identified By Monoclonal Antibody GA733,Cell Surface Glycoprotein TROP2,Epithelial Glycoprotein
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:19
Lastest Research Phase:Approved

Antibody Licensing

Project Name Project Stage Molecule Type Host Species Therapeutic Area Indications
Trop2 ADC -01 IND Solid Tumor Non-small cell lung cancer,Pancreatic cancer

製品リスト製品比較と製品注文

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製造番号 種類 製品説明 構造 純度 特徴
TR2-C52H5 Cynomolgus Cynomolgus TROP-2 / TACSTD2 Protein, His Tag (MALS verified)
TR2-C52H5-structure
TR2-C52H5-sds
TR2-C82E3 Cynomolgus Biotinylated Cynomolgus TROP-2 / TACSTD2 Protein, His,Avitag™ (MALS verified)
TR2-C82E3-structure
TR2-C82E3-sds
TR2-M82F3 Mouse Biotinylated Mouse TROP-2 / TACSTD2 Protein, Fc,Avitag™ (MALS verified)
TR2-M82F3-structure
TR2-M82F3-sds
TR2-R5255 Rhesus macaque Rhesus macaque TROP-2 / TACSTD2 Protein, Fc Tag (MALS verified)
TR2-R5255-structure
TR2-R5255-sds
TR2-H52H6 Human Human TROP-2 / TACSTD2 (88-274) Protein, His Tag
TR2-H52H6-structure
TR2-H52H6-sds
TR2-R82F6 Rhesus macaque Biotinylated Rhesus macaque TROP-2 / TACSTD2 Protein, Fc,Avitag™ (MALS verified)
TR2-R82F6-structure
TR2-R82F6-sds
TR2-R82E7 Rhesus macaque Biotinylated Rhesus macaque TROP-2 / TACSTD2 Protein, His,Avitag™ (MALS verified)
TR2-R82E7-structure
TR2-R82E7-sds
TR2-M82E9 Mouse Biotinylated Mouse TROP-2 / TACSTD2 Protein, His,Avitag™ (MALS verified)
TR2-M82E9-structure
TR2-M82E9-sds
TR2-H82F4 Human Biotinylated Human TROP-2 / TACSTD2 Protein, Fc,Avitag™
TR2-H82F4-structure
TR2-H82F4-sds
TR2-R52H9 Rabbit Rabbit TROP-2 / TACSTD2 Protein, His Tag (MALS verified)
TR2-R52H9-structure
TR2-R52H9-sds
TR2-H82Ea Human Biotinylated Human TROP-2 / TACSTD2 (88-274) Protein, His,Avitag™ (MALS verified)
TR2-H82Ea-structure
TR2-H82Ea-sds
MBS-K028 Human Human TROP-2-coupled Magnetic Beads
TR2-C52H4 Canine Canine TROP-2 / TACSTD2 Protein, His Tag
TR2-C52H4-structure
TR2-C52H4-sds
TR2-R52H3 Rhesus macaque Rhesus macaque TROP-2 / TACSTD2 Protein, His Tag (MALS verified)
TR2-R52H3-structure
TR2-R52H3-sds
TR2-M52H6 Mouse Mouse TROP-2 / TACSTD2 Protein, His Tag (MALS verified)
TR2-M52H6-structure
TR2-M52H6-sds
TR2-H5253 Human Human TROP-2 / TACSTD2 Protein, Fc Tag (MALS verified)
TR2-H5253-structure
TR2-H5253-sds
TR2-H82E5 Human Biotinylated Human TROP-2 / TACSTD2 Protein, His,Avitag™ (MALS verified)
TR2-H82E5-structure
TR2-H82E5-sds
TR2-H5223 Human Human TROP-2 / TACSTD2 Protein, His Tag (MALS verified)
TR2-H5223-structure
TR2-H5223-sds
ACRO Quality

生物活性データの一部

TR2-R52H3-SPR
TROP-2 SPR

Captured Trop2 antibody on CM5 chip via anti-mouse antibodies surface can bind Rhesus macaque TROP-2 Protein, His Tag (Cat. No. TR2-R52H3) with an affinity constant of 5.48 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol
TR2-H5253-SPR
TROP-2 SPR

Captured Trop2 antibody on CM5 chip via anti-mouse antibodies surface can bind Human TROP-2, Fc Tag (Cat. No. TR2-H5253) with an affinity constant of 3.45 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol

カスタマーレビュー

Synonym Name

TACSTD2,GA733-1,M1S1,TROP2

Background

TROP-2 is a single-copy gene in human cells, and encodes a type-1 transmembrane glycoprotein which is over-expressed in various malignancies, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1. TROP-2 is related to epithelial cell adhesion molecule (EpCAM), also called TROP-1, gp40, and KSA. Trop-1 and Trop-2 are homologous to serum IGF-II-binding proteins and appear as signal transducers. Thus, they likely represent novel cell-surface receptors and may play a role in regulating the growth of carcinoma cells.

Clinical and Translational Updates

公開薬物情報

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Sacituzumab govitecan IMMU0132; GS-0132; IMMU-0132; IMMU-132; TROP-2-SN-38 Approved Trodelvy, 拓达维, TRODELVY United States Triple Negative Breast Neoplasms Immunomedics Inc 2020-04-22 Brain metastases; Urinary Bladder Neoplasms; Klatskin Tumor; Breast Neoplasms; Prostatic Neoplasms; Cholangiocarcinoma; Bile Duct Neoplasms; Metastatic breast cancer; Esophageal Squamous Cell Carcinoma; Thyroid Carcinoma, Anaplastic; Endometrial Neoplasms; Thymoma; Thyroid Neoplasms; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis; Uterine Cervical Neoplasms; Carcinoma, Hepatocellular; Solid tumours; Neoplasms; Salivary Gland Neoplasms; Pancreatic Neoplasms; Small Cell Lung Carcinoma; Carcinoma, Ovarian Epithelial; Glioblastoma; Triple Negative Breast Neoplasms; Carcinoma, Transitional Cell; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Esophageal Neoplasms; Stomach Neoplasms; Biliary Tract Neoplasms; Ovarian Neoplasms; Liver Failure Details
Sacituzumab govitecan IMMU0132; GS-0132; IMMU-0132; IMMU-132; TROP-2-SN-38 Approved Trodelvy, 拓达维, TRODELVY United States Triple Negative Breast Neoplasms Immunomedics Inc 2020-04-22 Brain metastases; Urinary Bladder Neoplasms; Klatskin Tumor; Breast Neoplasms; Prostatic Neoplasms; Cholangiocarcinoma; Bile Duct Neoplasms; Metastatic breast cancer; Esophageal Squamous Cell Carcinoma; Thyroid Carcinoma, Anaplastic; Endometrial Neoplasms; Thymoma; Thyroid Neoplasms; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis; Uterine Cervical Neoplasms; Carcinoma, Hepatocellular; Solid tumours; Neoplasms; Salivary Gland Neoplasms; Pancreatic Neoplasms; Small Cell Lung Carcinoma; Carcinoma, Ovarian Epithelial; Glioblastoma; Triple Negative Breast Neoplasms; Carcinoma, Transitional Cell; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Esophageal Neoplasms; Stomach Neoplasms; Biliary Tract Neoplasms; Ovarian Neoplasms; Liver Failure Details

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
SHR-A1921 SHR-A1921; SHRA1921; SHR-1921 Phase 3 Clinical Suzhou Suncadia Biopharmaceuticals Co Ltd, Shanghai Hengrui Pharmaceutical Co Ltd Solid tumours; Ovarian Neoplasms; Triple Negative Breast Neoplasms; Neoplasms; Salivary Gland Neoplasms; Breast Neoplasms; Brain metastases Details
OBI-992 OBI-992 Phase 2 Clinical Obi Pharma Usa Inc Solid tumours; Stomach Neoplasms; Small Cell Lung Carcinoma; Carcinoma, Non-Small-Cell Lung Details
HS-20105 HS-20105; HS20105 Phase 2 Clinical Hansoh BioMedical R&D Company Solid tumours Details
IBI130 IBI130; IBI-130 Phase 2 Clinical Innovent Biologics(Suzhou) Co Ltd Solid tumours; Neoplasm Metastasis Details
Anti TROP2 antibody drug conjugate ADC（Fudan University） Phase 2 Clinical Fudan University Triple Negative Breast Neoplasms Details
9MW-2921 9MW2921; 9MW-2921 Phase 2 Clinical Mabwell (Shanghai) Bioscience Co Ltd Solid tumours Details
MHB036C MHB-036C Phase 2 Clinical Minghui Pharmaceutical Pty Ltd Solid tumours Details
BAT-8008 BAT8008; BAT-8008 Phase 2 Clinical Bio-Thera Solutions Ltd Solid tumours Details
DB-1305 DB1305; BNT325; DB-1305; BNT-325 Phase 2 Clinical Solid tumours Details
BIO-106 BIO-106 Phase 2 Clinical Hangzhou Baikai Biopharmaceutical Co Ltd Solid tumours; Neoplasms Details
BL-M02D1 Phase 2 Clinical Baili-Bio (Chengdu) Pharmaceutical Co Ltd Solid tumours; Triple Negative Breast Neoplasms; Digestive System Neoplasms; Breast Neoplasms; Gastrointestinal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
LCB-84 LCB-84 Phase 2 Clinical Legochem Biosciences Inc Solid tumours Details
重组人源化抗Trop2单抗-SN38偶联物 ESG-401; STI-3258 Phase 2 Clinical Shanghai Escugen Biotechnology Co Ltd Solid tumours; Ovarian Neoplasms; Stomach Neoplasms; Neoplasms; Urinary Bladder Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Lung Neoplasms Details
FDA018 Antibody Drug Conjugate FDA018-ADC; FDA-018-ADC Phase 2 Clinical Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co Ltd Solid tumours; Neoplasms; Triple Negative Breast Neoplasms; Breast Neoplasms; Neoplasm Metastasis Details
DAC-002 DAC-002; JS-108 Phase 1 Clinical Hangzhou Dac Biotech Company Ltd Solid tumours; Triple Negative Breast Neoplasms; Small Cell Lung Carcinoma Details
MT-302 MT-302 Phase 1 Clinical Myeloid Therapeutics Inc Carcinoma; Colonic Neoplasms; Breast Neoplasms; Lung Neoplasms Details
SHR-A1921 SHR-A1921; SHRA1921; SHR-1921 Phase 3 Clinical Suzhou Suncadia Biopharmaceuticals Co Ltd, Shanghai Hengrui Pharmaceutical Co Ltd Solid tumours; Ovarian Neoplasms; Triple Negative Breast Neoplasms; Neoplasms; Salivary Gland Neoplasms; Breast Neoplasms; Brain metastases Details
OBI-992 OBI-992 Phase 2 Clinical Obi Pharma Usa Inc Solid tumours; Stomach Neoplasms; Small Cell Lung Carcinoma; Carcinoma, Non-Small-Cell Lung Details
HS-20105 HS-20105; HS20105 Phase 2 Clinical Hansoh BioMedical R&D Company Solid tumours Details
IBI130 IBI130; IBI-130 Phase 2 Clinical Innovent Biologics(Suzhou) Co Ltd Solid tumours; Neoplasm Metastasis Details
Anti TROP2 antibody drug conjugate ADC（Fudan University） Phase 2 Clinical Fudan University Triple Negative Breast Neoplasms Details
9MW-2921 9MW2921; 9MW-2921 Phase 2 Clinical Mabwell (Shanghai) Bioscience Co Ltd Solid tumours Details
MHB036C MHB-036C Phase 2 Clinical Minghui Pharmaceutical Pty Ltd Solid tumours Details
BAT-8008 BAT8008; BAT-8008 Phase 2 Clinical Bio-Thera Solutions Ltd Solid tumours Details
DB-1305 DB1305; BNT325; DB-1305; BNT-325 Phase 2 Clinical Solid tumours Details
BIO-106 BIO-106 Phase 2 Clinical Hangzhou Baikai Biopharmaceutical Co Ltd Solid tumours; Neoplasms Details
BL-M02D1 Phase 2 Clinical Baili-Bio (Chengdu) Pharmaceutical Co Ltd Solid tumours; Triple Negative Breast Neoplasms; Digestive System Neoplasms; Breast Neoplasms; Gastrointestinal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
LCB-84 LCB-84 Phase 2 Clinical Legochem Biosciences Inc Solid tumours Details
重组人源化抗Trop2单抗-SN38偶联物 ESG-401; STI-3258 Phase 2 Clinical Shanghai Escugen Biotechnology Co Ltd Solid tumours; Ovarian Neoplasms; Stomach Neoplasms; Neoplasms; Urinary Bladder Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Lung Neoplasms Details
FDA018 Antibody Drug Conjugate FDA018-ADC; FDA-018-ADC Phase 2 Clinical Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co Ltd Solid tumours; Neoplasms; Triple Negative Breast Neoplasms; Breast Neoplasms; Neoplasm Metastasis Details
DAC-002 DAC-002; JS-108 Phase 1 Clinical Hangzhou Dac Biotech Company Ltd Solid tumours; Triple Negative Breast Neoplasms; Small Cell Lung Carcinoma Details
MT-302 MT-302 Phase 1 Clinical Myeloid Therapeutics Inc Carcinoma; Colonic Neoplasms; Breast Neoplasms; Lung Neoplasms Details

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