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Your Position: ホーム > CD200

CD200

概要

Name:OX-2 membrane glycoprotein
Target Synonym:My033,CD200,CD200 Antigen,Antigen Identified By Monoclonal Antibody MRC OX-2,MOX1,OX-2 Membrane Glycoprotein,OX-2,MRC,CD200 Molecule,MOX2
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 2 Clinical

ライセンス

Project Name Modality Therapeutic Area Indications Stage Right Available
Orexin Receptor Antagonist (OX1R and OX2R) Small molecule Neurological disease Insomnia Disorder Phase III Global  (except China)

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製造番号 種類 製品説明 構造 純度 特徴
OX2-M82F3 Mouse Biotinylated Mouse CD200 / OX-2 Protein, Fc,Avitag™ (MALS verified)
OX2-M82F3-structure
OX2-M82F3-sds
OX2-H82F1 Human Biotinylated Human CD200 / OX-2 Protein, Fc,Avitag™
OX2-H82F1-structure
OX2-H82F1-sds
OX2-H5228 Human Human CD200 / OX-2 Protein, His Tag
OX2-H5228-structure
OX2-H5228-sds
OX2-H5251 Human Human CD200 / OX-2 Protein, Fc Tag
OX2-H5251-structure
OX2-H5251-sds
ACRO Quality

生物活性データの一部

OX2-H82F1-ELISA
Biotinylated Human CD200, Fc,AvitagBiotinylated Human CD200, Fc,Avitag (Cat. No. OX2-H82F1) ELISA bioactivity

Immobilized Human CD200 R1, His Tag (Cat. No. CR2-H52H6) at 5 μg/mL (100 μL/well) can bind Biotinylated Human CD200, Fc,Avitag (Cat. No. OX2-H82F1) with a linear range of 0.2-2 ng/mL (QC tested).

Protocol
OX2-M82F3-MALS-HPLC
Biotinylated Mouse CD200, Fc,Avitag (Cat. No. ) MALS images

The purity of Biotinylated Mouse CD200, Fc,Avitag (Cat. No. OX2-M82F3) is more than 90% and the molecular weight of this protein is around 125-135 kDa verified by SEC-MALS.

Report
Bioactivity-ELISA
Biotinylated Mouse CD200, Fc,AvitagBiotinylated Mouse CD200, Fc,Avitag (Cat. No. OX2-M82F3) ELISA bioactivity

Immobilized Human CD200 R1, His Tag (Cat. No. CR2-H52H6) at 5 μg/mL (100 μL/well) can bind Biotinylated Mouse CD200, Fc,Avitag (Cat. No. OX2-M82F3) with a linear range of 0.02-0.5 μg/mL (QC tested).

Synonym Name

CD200,MOX1,MOX2,MRC,OX-2,My033

Background

CD200 is also known as OX-2 membrane glycoprotein (OX-2), is a type-1 membrane glycoprotein, which contains two immunoglobulin domains (1 Ig-like C2-type (immunoglobulin-like) domain and Ig-like V-type (immunoglobulin-like) domain), and thus belongs to the immunoglobulin superfamily. CD200 / OX-2 is widely expressed in multiple cell types. CD200 interacts with a structurally related receptor (CD200R) expressed mainly on myeloid cells and is involved in regulation of macrophage and mast cell function. OX-2 / CD200 and CD200R associate via their respective N-terminal Ig-like domains. CD200 also plays an important role in prevention of graft rejection, autoimmune diseases and spontaneous abortion.

Clinical and Translational Updates

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
P-006 P-006; 23ME-610; 23ME-00610 Phase 2 Clinical 23andme Inc Solid tumours; Carcinoma, Renal Cell; Small Cell Lung Carcinoma; Carcinoma, Ovarian Epithelial; Neuroendocrine Tumors; Peritoneal Neoplasms; Fallopian Tube Neoplasms Details
CD-200-AR-L CD-200-AR-L; hP-1-A-8 Phase 1 Clinical University Of Minnesota, OX2 Therapeutics Glioblastoma; Glioma Details
P-006 P-006; 23ME-610; 23ME-00610 Phase 2 Clinical 23andme Inc Solid tumours; Carcinoma, Renal Cell; Small Cell Lung Carcinoma; Carcinoma, Ovarian Epithelial; Neuroendocrine Tumors; Peritoneal Neoplasms; Fallopian Tube Neoplasms Details
CD-200-AR-L CD-200-AR-L; hP-1-A-8 Phase 1 Clinical University Of Minnesota, OX2 Therapeutics Glioblastoma; Glioma Details

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