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Your Position: ホーム > CD7

CD7

概要

Name:T-cell antigen CD7
Target Synonym:T-cell antigen CD7,GP40,CD7,TP41,CD7 Molecule,T-Cell Leukemia Antigen,T-Cell Surface Antigen Leu-9,CD7 Antigen (P41),P41 Protein,CD7 Antigen,LEU-9,Tp40,Antigens, CD7
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:24
Lastest Research Phase:Phase 2 Clinical

Antibody Licensing

Project Name Project Stage Molecule Type Host Species Therapeutic Area Indications
CD7 VHH - 01 Lead Hematological Malignancy Non-hodgkin lymphoma

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製造番号 種類 製品説明 構造 純度 特徴
CD7-C82F4 Cynomolgus Biotinylated Cynomolgus CD7 Protein, Fc,Avitag™ (MALS verified)
CD7-C82F4-structure
CD7-C82F4-sds
CD7-C52H7 Cynomolgus Cynomolgus CD7 Protein, His Tag (MALS & SPR verified)
CD7-C52H7-structure
CD7-C52H7-sds
CD7-C82E8 Cynomolgus Biotinylated Cynomolgus CD7 Protein, His,Avitag™ (MALS & SPR verified)
CD7-C82E8-structure
CD7-C82E8-sds
MBS-C005 Human ActiveMax® Human CD7 μBeads, premium grade (for cells)
CD7-HA2H6 Human APC-Labeled Human CD7 Protein, His TagStar Staining
CD7-HA2H6-structure
CD7-HA2H3 Human APC-Labeled Human CD7 Protein, His Tag (Site-specific conjugation)
CD7-HA2H3-structure
CD7-HA2H9 Human Alexa Fluor™ 488-Labeled Human CD7 Protein, His TagStar Staining
CD7-HA2H9-structure
CD7-HP2H6 Human PE-Labeled Human CD7 Protein, His TagStar Staining
CD7-M52H3 Mouse Mouse CD7 Protein, His Tag
CD7-M52H3-structure
CD7-M52H3-sds
CD7-HF258 Human FITC-Labeled Human CD7 Protein, Fc Tag
CD7-HF258-structure
CD7-HF258-sds
CD7-HP2E3 Human PE-Labeled Human CD7 Protein, His Tag (Site-specific conjugation)
CD7-HP2E3-structure
CD7-H82F3 Human Biotinylated Human CD7 Protein, Fc,Avitag™ (MALS verified)
CD7-H82F3-structure
CD7-H82F3-sds
CD7-H5253 Human Human CD7 Protein, Fc Tag (MALS verified)
CD7-H5253-structure
CD7-H5253-sds
CD7-H82E4 Human Biotinylated Human CD7 Protein, His,Avitag™, premium grade
CD7-H82E4-structure
CD7-H82E4-sds
CD7-HF257 Human FITC-Labeled Human CD7 Protein, Llama IgG2b Fc Tag
CD7-HF257-structure
CD7-HF257-sds
CD7-HF2H6 Human FITC-Labeled Human CD7 Protein, His Tag
CD7-HF2H6-structure
CD7-HF2H6-sds
CD7-H52H7 Human Human CD7 Protein, His Tag (MALS verified)
CD7-H52H7-structure
CD7-H52H7-sds
CD7-H5258 Human Human CD7 Protein, Llama IgG2b Fc Tag, low endotoxin
CD7-H5258-structure
CD7-H5258-sds
ACRO Quality

生物活性データの一部

CD7-HP2H6-Cell-based assay
CD7 CAR_T

5e5 of anti-CD7 CAR-293 cells were stained with 100 μL of 1:50 dilution (2 μL stock solution in 100 μL FACS buffer) of PE-Labeled Human CD7 Protein, His Tag (Cat. No. CD7-HP2H6) and negative control protein respectively (Fig. C and B), and non-transfected 293 cells were used as a control (Fig. A). PE signal was used to evaluate the binding activity (QC tested).

Protocol
CD7-C52H7-SPR
CD7 SPR

Cynomolgus CD7 Protein, His Tag (Cat. No. CD7-C52H7) immobilized on CM5 Chip can bind Human SECTM1, His Tag (Cat. No. SE1-H5227) with an affinity constant of 24.7 nM as determined in a SPR assay (Biacore 8K) (QC tested).

Protocol
CD7-C82E8-SPR
CD7 SPR

Biotinylated Cynomolgus CD7 Protein, His,Avitag (Cat. No. CD7-C82E8) immobilized on CM5 Chip can bind Human SECTM1, His Tag (Cat. No. SE1-H5227) with an affinity constant of 12.4 nM as determined in a SPR assay (Biacore 8K) (QC tested).

Protocol

カスタマーレビュー

Synonym Name

CD7,GP40,TP41,LEU-9,Tp40

Background

T-cell antigen CD7 (CD7) is also known as GP40, LEU-9, TP41 and Tp40. CD7 is a protein that in humans is encoded by the CD7 gene, this gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily. CD7 has been shown to interact with PIK3R1. This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development.

Clinical and Translational Updates

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
Anti-CD7 and anti-CD19 chimeric antigen receptor T cell therapy GC-197 Phase 2 Clinical Gracell Biotechnologies (Shanghai) Co Ltd Precursor B-Cell Lymphoblastic Leukemia-Lymphoma Details
BEAM-201 BEAM-201 Phase 2 Clinical Beam Therapeutics Inc Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, T-Cell Details
Autologous and Donor-derived CD7 CAR-T Therapy(Beijing GoBroad Hospital) Phase 2 Clinical Beijing GoBroad Hospital Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Details
CD7-CAR-T Cells Therapy CD7-CART01 Phase 2 Clinical Bambino Gesu Hospital And Research Institute Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Details
Humanized CD7 CAR-T cells Phase 2 Clinical The First Affiliated Hospital Of Soochow University Lymphoma, T-Cell Details
WU-CART-007 WU-CART-007 Phase 2 Clinical Wugen Inc Lymphoma, T-Cell, Peripheral; Enteropathy-Associated T-Cell Lymphoma; Leukemia-Lymphoma, Adult T-Cell; Lymphoma, Primary Cutaneous Anaplastic Large Cell; Lymphoma, Extranodal NK-T-Cell; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sezary Syndrome; Lymphoma, Large-Cell, Anaplastic; Leukemia, Myeloid, Acute; Lymphoma, T-Cell; Leukemia, Prolymphocytic, T-Cell; Mycosis Fungoides Details
Anti-CD7 CAR T-cell therapy (Yake Biotechnology) Phase 2 Clinical Shanghai YaKe Biotechnology Co Ltd Leukemia; Still's Disease, Adult-Onset; Hematologic Diseases; Dermatomyositis; Neoplasms; Autoimmune Diseases; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Colitis, Ulcerative; Lymphoma; Lymphoma, T-Cell; Crohn Disease; Leukemia, T-Cell Details
CD7-CAR-T cell therapy (PersonGen Biomedicine) Phase 2 Clinical Persongen Biotherapeutics (Suzhou) Co Ltd, The First Affiliated Hospital Of Zhengzhou University Leukemia; Enteropathy-Associated T-Cell Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Extranodal NK-T-Cell; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Large-Cell, Anaplastic; Leukemia, Myeloid, Acute; Lymphoma, T-Cell Details
GC-027 GC-027 Phase 1 Clinical Gracell Biotechnologies (Shanghai) Co Ltd Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Details
MB-107(March Biosciences) MB-107(March Biosciences) Phase 1 Clinical March Biosciences Inc Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, T-Cell Details
Universal 4SCAR7U T Cell Therapy (Shenzhen Geno-Immune Medical Institute) 4SCAR7U T cells Phase 1 Clinical Shenzhen Geno-Immune Medical Institute Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myeloid, Acute; Lymphoma Details
RD13-02 RD13-02 Phase 1 Clinical Nanjing Bioheng Biotech Co Ltd, Zhejiang University Hematologic Neoplasms; Hematologic Diseases; Neoplasms Details
Anti-CD7 Chimeric Antigen Receptor T-Cell therapy(Bioceltech Therapeutics) BT-007 Phase 1 Clinical Gracell Biotechnologies (Shanghai) Co Ltd, Bioceltech Therapeutics Ltd Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Details
BE CAR-7 BE-CAR-7 Phase 1 Clinical Great Ormond Street Hospital For Children Nhs Foundation Trust Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Prolymphocytic, T-Cell Details
Anti-CD7 CAR-T cell Therapy (Shanghai General Hospital) Phase 1 Clinical Shanghai General Hospital Lymphoma, T-Cell, Peripheral; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Large-Cell, Anaplastic; Leukemia, T-Cell Details
This CAR-T-7 cells therapy This CAR-T-7 cells Phase 1 Clinical Fundamenta Therapeutics Ltd Leukemia, Lymphoid; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, T-Cell Details
GC-502 GC-502 Phase 1 Clinical Gracell Biotechnologies (Shanghai) Co Ltd Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Non-Hodgkin Details
CD7 CARvac T cell therapy Phase 1 Clinical Icell Gene Therapeutics (Int'L) Ltd Hematologic Neoplasms; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma Details
SenL-T7 CAR T Cells (Hebei Senlang Biological) Senl-T7; Senl-T-7; SENL-101 Phase 1 Clinical Hebei Senlang Biological Technology Co Ltd Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, T-Cell; Leukemia, T-Cell Details
PA3-17 PA3-17; PA-3-17; PA3-17 (autologous) Phase 1 Clinical Persongen Anke Cell Technology Co Ltd, Persongen Biotherapeutics (Suzhou) Co Ltd Hematologic Neoplasms; Lymphoma Details
CAR7-T Cell Therapy (Beijing Gaobo Biotechnology Co Ltd) Phase 1 Clinical Wuhan Union Hospital Lymphoma, T-Cell; Leukemia, T-Cell; Leukemia, Lymphocytic, Chronic, B-Cell Details
CD7 targeted CAR-γδ T cells therapy(Persongen Bio) Phase 1 Clinical Persongen Biotherapeutics (Suzhou) Co Ltd Neoplasms; Leukemia, B-Cell Details
CD7 CAR-T cell therapy (Hebei Senlang Biotechnology) Phase 1 Clinical Hebei Senlang Biological Technology Co Ltd Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma Details
RD13-01 RD13-01; CTD-401 Clinical Zhejiang University, Nanjing Bioheng Biotech Co Ltd Hematologic Neoplasms Details
Anti-CD7 CAR-T Cell Therapy (iCell Gene Therapeutics) iCell Gene Therapeutics LLC Details
Anti-CD7 and anti-CD19 chimeric antigen receptor T cell therapy GC-197 Phase 2 Clinical Gracell Biotechnologies (Shanghai) Co Ltd Precursor B-Cell Lymphoblastic Leukemia-Lymphoma Details
BEAM-201 BEAM-201 Phase 2 Clinical Beam Therapeutics Inc Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, T-Cell Details
Autologous and Donor-derived CD7 CAR-T Therapy(Beijing GoBroad Hospital) Phase 2 Clinical Beijing GoBroad Hospital Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Details
CD7-CAR-T Cells Therapy CD7-CART01 Phase 2 Clinical Bambino Gesu Hospital And Research Institute Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Details
Humanized CD7 CAR-T cells Phase 2 Clinical The First Affiliated Hospital Of Soochow University Lymphoma, T-Cell Details
WU-CART-007 WU-CART-007 Phase 2 Clinical Wugen Inc Lymphoma, T-Cell, Peripheral; Enteropathy-Associated T-Cell Lymphoma; Leukemia-Lymphoma, Adult T-Cell; Lymphoma, Primary Cutaneous Anaplastic Large Cell; Lymphoma, Extranodal NK-T-Cell; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sezary Syndrome; Lymphoma, Large-Cell, Anaplastic; Leukemia, Myeloid, Acute; Lymphoma, T-Cell; Leukemia, Prolymphocytic, T-Cell; Mycosis Fungoides Details
Anti-CD7 CAR T-cell therapy (Yake Biotechnology) Phase 2 Clinical Shanghai YaKe Biotechnology Co Ltd Leukemia; Still's Disease, Adult-Onset; Hematologic Diseases; Dermatomyositis; Neoplasms; Autoimmune Diseases; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Colitis, Ulcerative; Lymphoma; Lymphoma, T-Cell; Crohn Disease; Leukemia, T-Cell Details
CD7-CAR-T cell therapy (PersonGen Biomedicine) Phase 2 Clinical Persongen Biotherapeutics (Suzhou) Co Ltd, The First Affiliated Hospital Of Zhengzhou University Leukemia; Enteropathy-Associated T-Cell Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Extranodal NK-T-Cell; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Large-Cell, Anaplastic; Leukemia, Myeloid, Acute; Lymphoma, T-Cell Details
GC-027 GC-027 Phase 1 Clinical Gracell Biotechnologies (Shanghai) Co Ltd Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Details
MB-107(March Biosciences) MB-107(March Biosciences) Phase 1 Clinical March Biosciences Inc Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, T-Cell Details
Universal 4SCAR7U T Cell Therapy (Shenzhen Geno-Immune Medical Institute) 4SCAR7U T cells Phase 1 Clinical Shenzhen Geno-Immune Medical Institute Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myeloid, Acute; Lymphoma Details
RD13-02 RD13-02 Phase 1 Clinical Nanjing Bioheng Biotech Co Ltd, Zhejiang University Hematologic Neoplasms; Hematologic Diseases; Neoplasms Details
Anti-CD7 Chimeric Antigen Receptor T-Cell therapy(Bioceltech Therapeutics) BT-007 Phase 1 Clinical Gracell Biotechnologies (Shanghai) Co Ltd, Bioceltech Therapeutics Ltd Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Details
BE CAR-7 BE-CAR-7 Phase 1 Clinical Great Ormond Street Hospital For Children Nhs Foundation Trust Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Prolymphocytic, T-Cell Details
Anti-CD7 CAR-T cell Therapy (Shanghai General Hospital) Phase 1 Clinical Shanghai General Hospital Lymphoma, T-Cell, Peripheral; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Large-Cell, Anaplastic; Leukemia, T-Cell Details
This CAR-T-7 cells therapy This CAR-T-7 cells Phase 1 Clinical Fundamenta Therapeutics Ltd Leukemia, Lymphoid; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, T-Cell Details
GC-502 GC-502 Phase 1 Clinical Gracell Biotechnologies (Shanghai) Co Ltd Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Non-Hodgkin Details
CD7 CARvac T cell therapy Phase 1 Clinical Icell Gene Therapeutics (Int'L) Ltd Hematologic Neoplasms; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma Details
SenL-T7 CAR T Cells (Hebei Senlang Biological) Senl-T7; Senl-T-7; SENL-101 Phase 1 Clinical Hebei Senlang Biological Technology Co Ltd Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, T-Cell; Leukemia, T-Cell Details
PA3-17 PA3-17; PA-3-17; PA3-17 (autologous) Phase 1 Clinical Persongen Anke Cell Technology Co Ltd, Persongen Biotherapeutics (Suzhou) Co Ltd Hematologic Neoplasms; Lymphoma Details
CAR7-T Cell Therapy (Beijing Gaobo Biotechnology Co Ltd) Phase 1 Clinical Wuhan Union Hospital Lymphoma, T-Cell; Leukemia, T-Cell; Leukemia, Lymphocytic, Chronic, B-Cell Details
CD7 targeted CAR-γδ T cells therapy(Persongen Bio) Phase 1 Clinical Persongen Biotherapeutics (Suzhou) Co Ltd Neoplasms; Leukemia, B-Cell Details
CD7 CAR-T cell therapy (Hebei Senlang Biotechnology) Phase 1 Clinical Hebei Senlang Biological Technology Co Ltd Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma Details
RD13-01 RD13-01; CTD-401 Clinical Zhejiang University, Nanjing Bioheng Biotech Co Ltd Hematologic Neoplasms Details
Anti-CD7 CAR-T Cell Therapy (iCell Gene Therapeutics) iCell Gene Therapeutics LLC Details

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