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Your Position: ホーム > 4-1BB Ligand

4-1BB Ligand

概要

Name:Tumor necrosis factor ligand superfamily member 9
Target Synonym:4-1BB ligand,4-1BBL
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 2 Clinical

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製造番号 種類 製品説明 構造 純度 特徴
RES-A036 Human resDetect™ Human 4-1BB Ligand ELISA Kit (Residue Testing)
GMP-41LH26 Human GMP Human 4-1BB Ligand Protein, Fc Tag
GMP-41LH26-structure
GMP-41LH26-sds
MBS-C012 Human ActiveMax® Human 4-1BB Ligand / TNFSF9 (71-254) μBeads, premium grade (for cells)
41L-H82Fa Human Biotinylated Human 4-1BB Ligand / TNFSF9 (71-254) Protein, Fc,Avitag™, premium grade
41L-H82Fa-sds
CHEK-ATP039 Human HEK293/Human 4-1BB Ligand / TNFSF9 Stable Cell Line
41L-H5269 Human Human 4-1BB Ligand / TNFSF9 (71-254) Protein, Fc Tag, active trimer, premium grade
41L-H5269-structure
41L-H5269-sds
41L-C5254 Cynomolgus Cynomolgus 4-1BB Ligand / TNFSF9 Protein, Fc Tag, active trimer (MALS verified)
41L-C5254-sds
41L-R52D3 Rat Rat 4-1BB Ligand / TNFSF9 Protein, His,Flag Tag (MALS verified)
41L-R52D3-structure
41L-R52D3-sds
41L-H52D4 Human Human 4-1BB Ligand / TNFSF9 (71-254) Protein, His,Flag Tag, active trimer (MALS verified)
41L-H52D4-sds
41L-H82F9 Human Biotinylated Human 4-1BB Ligand / TNFSF9 Protein, Fc,Avitag™, premium grade
41L-H82F9-structure
41L-H82F9-sds
41L-M5257 Mouse Mouse 4-1BB Ligand / TNFSF9 Protein, Fc Tag
41L-M5257-structure
41L-M5257-sds
ACRO Quality

生物活性データの一部

CHEK-ATP039-Cell-based assay
4-1BB Ligand FACS

FACS assay shows that Biotinylated Human 4-1BB, Fc,Avitag (41B-H82F8) can bind to HEK293/Human 4-1BB Ligand / TNFSF9 Stable Cell Line (CHEK-ATP039). HEK293/Human 4-1BB Ligand / TNFSF9 Stable Cell was red line, Negative control HEK293 cells was grey line (QC tested).

Protocol
GMP-41LH26-Cell-based assay
4-1BB Ligand CELL

GMP Human 4-1BB Ligand Protein, Fc Tag (Cat. No. GMP-41LH26) induce IL‐8 secretion in HT1080 human CD137 cell line. The specific activity of GMP Human 4-1BB Ligand Protein, Fc Tag is＞1.00 x 10^5 U/mg (QC tested).

Protocol
41L-H82Fa-SPR
4-1BB Ligand SPR

Biotinylated Human 4-1BB Ligand (71-254), Fc,Avitag, premium grade (Cat. No. 41L-H82Fa) captured on Protein A Chip can bind Human 4-1BB, His Tag (Cat. No. 41B-H52Hc) with an affinity constant of 342 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol
41L-H52D4-BLI
4-1BB Ligand BLI

Loaded Mouse 4-1BB, Fc Tag (Cat. No. 41B-M5258) on Protein A Biosensor, can bind Human 4-1BB Ligand (71-254) Protein, His,Flag Tag (Cat. No. 41L-H52D4) with an affinity constant of 18.6 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol

Synonym Name

4-1BB Ligand,TNFSF9,CD137L

Background

Tumor necrosis factor ligand superfamily member 9 (4-1BBL) is also known as 4-1BB ligand, CD137L or TNFSF9, which is a cytokine that binds to TNFRSF9. 4-1BBL is the high affinity ligand of 4-1BB. 4-1BBL induces the proliferation of activated peripheral blood T-cells. Also, 4-1BBL may have a role in activation-induced cell death (AICD). Furthermore, 4-1BBL may play a role in cognate interactions between T-cells and B-cells/macrophages. As for diseases, 4-1BBL is involved in cancers, infectious diseases and autoimmune diseases.

Clinical and Translational Updates

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
RTX-224 RTX-224 Phase 2 Clinical Rubius Therapeutics Inc Skin Melanoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms; Carcinoma, Transitional Cell; Carcinoma, Non-Small-Cell Lung Details
RP-3 RP-3 Phase 2 Clinical Replimune Inc Solid tumours; Liver Neoplasms; Squamous Cell Carcinoma of Head and Neck; Colorectal Neoplasms; Carcinoma, Hepatocellular Details
RTX-224 RTX-224 Phase 2 Clinical Rubius Therapeutics Inc Skin Melanoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms; Carcinoma, Transitional Cell; Carcinoma, Non-Small-Cell Lung Details
RP-3 RP-3 Phase 2 Clinical Replimune Inc Solid tumours; Liver Neoplasms; Squamous Cell Carcinoma of Head and Neck; Colorectal Neoplasms; Carcinoma, Hepatocellular Details

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