ログイン 会員登録
icon_bulk_order一括注文 Acrobiosystems for English
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
phone
Your Position: ホーム > Protein > 4-1BB Ligand > 41L-M5257

Mouse 4-1BB Ligand / TNFSF9 Protein, Fc Tag

  • Synonym
    4-1BB Ligand,TNFSF9,CD137L
  • Source
    Mouse 4-1BB Ligand, Fc Tag(41L-M5257) is expressed from human 293 cells (HEK293). It contains AA Arg 104 - Glu 309 (Accession # NP_033430).
    Predicted N-terminus: Arg 104
  • Molecular Characterization
    4-1BB Ligand Structure

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 49.0 kDa. The protein migrates as 60-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
4-1BB Ligand SDS-PAGE

Mouse 4-1BB Ligand, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

Bioactivity-ELISA
 4-1BB Ligand ELISA

Immobilized Mouse 4-1BB, His Tag (Cat. No. 41B-M52H7) at 0.5 μg/mL (100 μL/well) can bind Mouse 4‑1BB Ligand, Fc Tag (Cat. No. 41L-M5257) with a linear range of 0.4-6 ng/mL (QC tested).

Bioactivity-BLI
 4-1BB Ligand BLI

Loaded Mouse 4-1BB Ligand, Fc Tag (Cat. No. 41L-M5257) on Protein A Biosensor, can bind Mouse 4-1BB, His Tag (Cat. No. 41B-M52H7) with an affinity constant of 4.8 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

 4-1BB Ligand BLI

Loaded Mouse 4-1BB Ligand, Fc Tag (Cat. No. 41L-M5257) on Protein A Biosensor, can bind Rat 4-1BB, His Tag (Cat. No. 41B-R52H3) with an affinity constant of 74.3 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

  • Background
    Tumor necrosis factor ligand superfamily member 9 (4-1BBL) is also known as 4-1BB ligand, CD137L or TNFSF9, which is a cytokine that binds to TNFRSF9. 4-1BBL is the high affinity ligand of 4-1BB. 4-1BBL induces the proliferation of activated peripheral blood T-cells. Also, 4-1BBL may have a role in activation-induced cell death (AICD). Furthermore, 4-1BBL may play a role in cognate interactions between T-cells and B-cells/macrophages. As for diseases, 4-1BBL is involved in cancers, infectious diseases and autoimmune diseases.
  • Clinical and Translational Updates

コメント (0)


ETD of in-stock products: 4 business days

価格(JPY) : 98,000

価格(JPY) : 739,200

プロモーション&展示



医薬品開発状況

  • Number of Launched Drugs:0 Details
  • Number of Drugs in Clinical Trials:2 Details
  • Latest Research Phase:Phase 2 Clinical

データシート&ドキュメンテーション

DMF請求
DMF (Drug Master File)

関連製品一覧

新製品

お問い合わせ&コメント

This web search service is supported by Google Inc.

totopphone