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Your Position: ホーム > Nectin-4

Nectin-4

概要

Name:Nectin-4
Target Synonym:PRR4,LNIR,Nectin cell adhesion molecule 4,PVRL4,Ig superfamily receptor LNIR,Poliovirus receptor-related protein 4,NECTIN4,Poliovirus Receptor-Related 4,Nectin-4,Nectin 4,EDSS1
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:10
Lastest Research Phase:Approved

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製造番号 種類 製品説明 構造 純度 特徴
NE4-H82E3 Human Biotinylated Human Nectin-4 Protein, His,Avitag™ (MALS verified)
NE4-H82E3-structure
NE4-H82E3-sds
NE4-C5253 Cynomolgus Cynomolgus Nectin-4 Protein, Fc Tag (MALS verified)
NE4-C5253-structure
NE4-C5253-sds
NE4-M82F5 Mouse Biotinylated Mouse Nectin-4 Protein, Fc,Avitag™ (MALS verified)
NE4-M82F5-structure
NE4-M82F5-sds
NE4-C82F6 Cynomolgus Biotinylated Cynomolgus Nectin-4 Protein, Fc,Avitag™ (MALS verified)
NE4-C82F6-structure
NE4-C82F6-sds
NE4-C82E5 Cynomolgus Biotinylated Cynomolgus Nectin-4 Protein, His,Avitag™ (MALS verified)
NE4-C82E5-structure
NE4-C82E5-sds
NE4-M82E7 Mouse Biotinylated Mouse Nectin-4 Protein, His,Avitag™ (MALS verified)
NE4-M82E7-structure
NE4-M82E7-sds
NE4-H82F4 Human Biotinylated Human Nectin-4 Protein, Fc,Avitag™ (MALS verified)
NE4-H82F4-structure
NE4-H82F4-sds
CHEK-ATP035 Human HEK293/Human Nectin-4 Stable Cell Line
MBS-K039 Human Human Nectin-4-coupled Magnetic Beads
NE4-H82Ea Human Biotinylated Human Nectin-4 (32-153) Protein, His,Avitag™ (MALS verified)
NE4-H82Ea-structure
NE4-H82Ea-sds
NE4-H82Ed Human Biotinylated Human Nectin-4 (244-349) Protein, His,Avitag™ (MALS verified)
NE4-H82Ed-structure
NE4-H82Ed-sds
NE4-H82Ec Human Biotinylated Human Nectin-4 (154-243) Protein, His,Avitag™
NE4-H82Ec-structure
NE4-H82Ec-sds
NE4-R5255 Rat Rat Nectin-4 Protein, Fc Tag (MALS verified)
NE4-R5255-structure
NE4-R5255-sds
NE4-M52Ha Mouse Mouse Nectin-4 Protein, His Tag, low endotoxin (MALS verified)
NE4-M52Ha-structure
NE4-M52Ha-sds
NE4-M5257 Mouse Mouse Nectin-4 Protein, Fc Tag (MALS verified)
NE4-M5257-structure
NE4-M5257-sds
NE4-HF2H3 Human FITC-Labeled Human Nectin-4 Protein, His Tag
NE4-HF2H3-structure
NE4-HF2H3-sds
NE4-H5255 Human Human Nectin-4 Protein, Fc Tag (MALS verified)
NE4-H5255-structure
NE4-H5255-sds
NE4-M52H3 Mouse Mouse Nectin-4 Protein, His Tag (MALS verified)
NE4-M52H3-structure
NE4-M52H3-sds
NE4-C52H4 Cynomolgus Cynomolgus Nectin-4 Protein, His Tag (MALS verified)
NE4-C52H4-structure
NE4-C52H4-sds
NE4-H82E7 Human Biotinylated Human Nectin-4 Protein, His,Avitag™ (MALS verified)
NE4-H82E7-structure
NE4-H82E7-sds
NE4-H52H3 Human Human Nectin-4 Protein, His Tag (MALS verified)
NE4-H52H3-structure
NE4-H52H3-sds
ACRO Quality

生物活性データの一部

CHEK-ATP035-Cell-based assay
Nectin-4 FACS

FACS analysis of Nectin-4 on HEK293/Human Nectin-4 Stable Cell Line.
FACS assay shows that Anti-Nectin-4 antibody can bind to HEK293/Human Nectin-4 Stable Cell Line. HEK293/Human Nectin-4 stable cells was red line, Negative control HEK293 cells was grey line (QC tested).

Protocol
NE4-HF2H3-Cell-based assay
Nectin-4 FACS

2e5 of anti-Nectin-4 CAR-293 cells were stained with 100 μL of 10 μg/mL of FITC-Labeled Human Nectin-4, His Tag (Cat. No. NE4-HF2H3) and negative control protein respectively, FITC signal was used to evaluate the binding activity (QC tested).

Protocol
NE4-C52H4-SPR
Nectin-4 SPR

Mouse Anti-Nectin-4 Antibody (Mouse IgG1) captured on CM5 chip via anti-mouse antibodies surface can bind Cynomolgus Nectin-4, His Tag (Cat. No. NE4-C52H4) with an affinity constant of 824 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol
NE4-H52H3-SPR
Nectin-4 SPR

Mouse Anti-Nectin-4 Antibody (Mouse IgG1) captured on CM5 chip via anti-mouse antibodies surface can bind Human Nectin-4, His Tag (Cat. No. NE4-H52H3) with an affinity constant of 58.2 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol

カスタマーレビュー

Synonym Name

NECTIN4,LNIR, PRR4, PVRL4

Background

Nectin-4 (gene name PVRL4, poliovirus receptor-like 4) is a 66 kDa type I transmembrane glycoprotein belonging to the Nectin family of Ig superfamily proteins. Nectins are cell adhesion molecules that play a key role in various biological processes such as polarity, proliferation, differentiation and migration, for epithelial, endothelial, immune and neuronal cells, during development and adult life. Nectin-4 is a tumor-associated antigen in 50%, 49% and 86%o of breast, ovarian and lung carcinomas, respectively, mostly on tumors of bad prognosis. Its expression is not detected in the corresponding normal tissues.

Clinical and Translational Updates

公開薬物情報

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Enfortumab vedotin DLE8519RWM; ASG-22ME; AGS-22M6E; ASG-22M6E; ASG-22CE; AGS-22ME; AGS-22C3; AGS-M6; AGS-22C3E Approved Agensys Inc Padcev United States Carcinoma, Transitional Cell Astellas Pharma Us Inc 2019-12-18 Kidney Neoplasms; Solid tumours; Carcinoma; Carcinoma, Transitional Cell; Pancreatic Neoplasms; Neoplasms; Prostatic Neoplasms, Castration-Resistant; Urinary Bladder Neoplasms; Urethral Neoplasms; Carcinoma in Situ; Ureteral Neoplasms; Urologic Neoplasms; Carcinoma, Pancreatic Ductal Details
Enfortumab vedotin DLE8519RWM; ASG-22ME; AGS-22M6E; ASG-22M6E; ASG-22CE; AGS-22ME; AGS-22C3; AGS-M6; AGS-22C3E Approved Agensys Inc Padcev United States Carcinoma, Transitional Cell Astellas Pharma Us Inc 2019-12-18 Kidney Neoplasms; Solid tumours; Carcinoma; Carcinoma, Transitional Cell; Pancreatic Neoplasms; Neoplasms; Prostatic Neoplasms, Castration-Resistant; Urinary Bladder Neoplasms; Urethral Neoplasms; Carcinoma in Situ; Ureteral Neoplasms; Urologic Neoplasms; Carcinoma, Pancreatic Ductal Details

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
9MW2821 9MW2821; 9MW-2821; 9-MW2821; 9-MW-2821 Phase 3 Clinical Mabwell (Shanghai) Bioscience Co Ltd Solid tumours; Carcinoma, Transitional Cell Details
BT-8009 BT-8009 Phase 3 Clinical Bicycle Tx Ltd Ovarian Neoplasms; Solid tumours; Triple Negative Breast Neoplasms; Carcinoma, Transitional Cell; Urinary Bladder Neoplasms; Carcinoma, Non-Small-Cell Lung Details
BT-7480 BT-7480 Phase 2 Clinical Bicycle Therapeutics Solid tumours; Neoplasms Details
SYS-6002 SYS-6002; SYS6002; CRB-701 Phase 2 Clinical Jushi Biopharmaceutical Co Ltd, CSPC Pharmaceutical Group Ltd Solid tumours Details
Nectin4/FAP-targeted CAR-T cell therapy (The Sixth Affiliated Hospital of Wenzhou Medical University) Phase 1 Clinical Wenzhou Medical University, The Sixth Affiliated Hospital Of Wenzhou Medical University Solid tumours Details
ETx-22 ETx-22; LY4101174 Phase 1 Clinical Emergence Therapeutics AG Ovarian Neoplasms; Solid tumours; Pelvic Neoplasms; Esophageal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Pancreatic Neoplasms; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Prostatic Neoplasms; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms; Neoplasm Metastasis Details
ADRX-0706 ADRX-0706 Phase 1 Clinical Adcentrx Therapeutics Inc Solid tumours; Neoplasms Details
SKB-410 SKB410; SKB-410 Phase 1 Clinical Sichuan Kelun-Biotech Biopharmaceutical Co Ltd Solid tumours Details
BAT-8007 BAT-8007 Phase 1 Clinical Bio-Thera Solutions Ltd Solid tumours Details
SHR-A2102 SHR-A2102 Phase 1 Clinical Shanghai Hengrui Pharmaceutical Co Ltd Solid tumours Details
9MW2821 9MW2821; 9MW-2821; 9-MW2821; 9-MW-2821 Phase 3 Clinical Mabwell (Shanghai) Bioscience Co Ltd Solid tumours; Carcinoma, Transitional Cell Details
BT-8009 BT-8009 Phase 3 Clinical Bicycle Tx Ltd Ovarian Neoplasms; Solid tumours; Triple Negative Breast Neoplasms; Carcinoma, Transitional Cell; Urinary Bladder Neoplasms; Carcinoma, Non-Small-Cell Lung Details
BT-7480 BT-7480 Phase 2 Clinical Bicycle Therapeutics Solid tumours; Neoplasms Details
SYS-6002 SYS-6002; SYS6002; CRB-701 Phase 2 Clinical Jushi Biopharmaceutical Co Ltd, CSPC Pharmaceutical Group Ltd Solid tumours Details
Nectin4/FAP-targeted CAR-T cell therapy (The Sixth Affiliated Hospital of Wenzhou Medical University) Phase 1 Clinical Wenzhou Medical University, The Sixth Affiliated Hospital Of Wenzhou Medical University Solid tumours Details
ETx-22 ETx-22; LY4101174 Phase 1 Clinical Emergence Therapeutics AG Ovarian Neoplasms; Solid tumours; Pelvic Neoplasms; Esophageal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Pancreatic Neoplasms; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Prostatic Neoplasms; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms; Neoplasm Metastasis Details
ADRX-0706 ADRX-0706 Phase 1 Clinical Adcentrx Therapeutics Inc Solid tumours; Neoplasms Details
SKB-410 SKB410; SKB-410 Phase 1 Clinical Sichuan Kelun-Biotech Biopharmaceutical Co Ltd Solid tumours Details
BAT-8007 BAT-8007 Phase 1 Clinical Bio-Thera Solutions Ltd Solid tumours Details
SHR-A2102 SHR-A2102 Phase 1 Clinical Shanghai Hengrui Pharmaceutical Co Ltd Solid tumours Details

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