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Your Position: ホーム > PTK7

PTK7

概要

Name:Protein-tyrosine kinase 7
Target Synonym:Colon carcinoma kinase 4,Inactive tyrosine-protein kinase 7,Tyrosine-protein kinase-like 7,CCK-4,PTK7,Protein Tyrosine Kinase 7 (Inactive),Pseudo Tyrosine Kinase Receptor 7,PTK7 Protein Tyrosine Kinase 7,CCK4,Protein-Tyrosine Kinase 7,Protein Tyrosine Kinase 7
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 2 Clinical

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製造番号 種類 製品説明 構造 純度 特徴
CHEK-ATP186 Human HEK293/Human PTK7 Stable Cell Line
PT7-M5256 Mouse Mouse PTK7 / CCK4 Protein, Fc Tag (MALS verified)
PT7-M5256-structure
PT7-M5256-sds
PT7-H82F5 Human Biotinylated Human PTK7 / CCK4 protein, Fc,Avitag™ (MALS verified)
PT7-H82F5-structure
PT7-H82F5-sds
PT7-R52H6 Rat Rat PTK7 / CCK4 Protein, His Tag (MALS verified)
PT7-R52H6-structure
PT7-R52H6-sds
PT7-R5255 Rat Rat PTK7 / CCK4 Protein, Fc Tag
PT7-R5255-structure
PT7-R5255-sds
PT7-C52H3 Cynomolgus / Rhesus macaque Cynomolgus / Rhesus macaque PTK7 / CCK4 Protein, His Tag (MALS verified)
PT7-C52H3-structure
PT7-C52H3-sds
PT7-R52H4 Rabbit Rabbit PTK7 / CCK4 Protein, His Tag (MALS verified)
PT7-R52H4-structure
PT7-R52H4-sds
PT7-M52H3 Mouse Mouse PTK7 / CCK4 Protein, His Tag (MALS verified)
PT7-M52H3-structure
PT7-M52H3-sds
PT7-H5253 Human Human PTK7 / CCK4 Protein, Fc Tag (MALS verified)
PT7-H5253-structure
PT7-H5253-sds
PT7-H82E5 Human Biotinylated Human PTK7 / CCK4 protein, His,Avitag™ (MALS verified)
PT7-H82E5-structure
PT7-H82E5-sds
PT7-H52H3 Human Human PTK7 / CCK4 Protein, His Tag (MALS verified)
PT7-H52H3-structure
PT7-H52H3-sds
ACRO Quality

生物活性データの一部

CHEK-ATP186-Cell-based assay
PTK7 FACS

Expression analysis of human PTK7 on HEK293/Human PTK7 Stable Cell Line by FACS.
Cell surface staining was performed on HEK293/Human PTK7 Stable Cell Line or negative control cell using anti-human PTK7 antibody followed by fixation with 4% paraformaldehyde, and then stained with PE anti-human IgG Fc antibody.

Protocol
PT7-C52H3-ELISA
PTK7 ELISA

Immobilized Cynomolgus / Rhesus macaque PTK7, His Tag (Cat. No. PT7-C52H3) at 1 μg/mL (100 μL/well) can bind Cofetuzumab Pelidotin with a linear range of 0.06-2 ng/mL (Routinely tested).

Protocol
PT7-M5256-MALS-HPLC
PTK7 MALS images

The purity of Mouse PTK7 Protein, Fc Tag (Cat. No. PT7-M5256) is more than 90% and the molecular weight of this protein is around 240-270 kDa verified by SEC-MALS.

カスタマーレビュー

Synonym Name

PTK7,CCK4,CCK-4,Tyrosine-protein kinase-like 7,Protein-tyrosine kinase 7,Protein-tyrosine kinase 7

Background

PTK7, highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.

Clinical and Translational Updates

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
PRO-1107 PRO-1107 Phase 2 Clinical ProfoundBio (Suzhou) Co Ltd Solid tumours; Ovarian Neoplasms; Stomach Neoplasms; Esophageal Neoplasms; Triple Negative Breast Neoplasms; Carcinoma, Transitional Cell; Endometrial Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Cofetuzumab Pelidotin PF-06647020; PF-6647020; PTK7-ADC; PF-06523435; PF-7020; hu-24; ABBV-647; Anti-PTK7 ADC; h6M24-vc0101 Phase 1 Clinical Abbvie Inc, Stemcentrx Inc Neoplasms; Carcinoma, Non-Small-Cell Lung Details
PRO-1107 PRO-1107 Phase 2 Clinical ProfoundBio (Suzhou) Co Ltd Solid tumours; Ovarian Neoplasms; Stomach Neoplasms; Esophageal Neoplasms; Triple Negative Breast Neoplasms; Carcinoma, Transitional Cell; Endometrial Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Cofetuzumab Pelidotin PF-06647020; PF-6647020; PTK7-ADC; PF-06523435; PF-7020; hu-24; ABBV-647; Anti-PTK7 ADC; h6M24-vc0101 Phase 1 Clinical Abbvie Inc, Stemcentrx Inc Neoplasms; Carcinoma, Non-Small-Cell Lung Details

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