ログイン 会員登録
icon_bulk_order一括注文 Acrobiosystems for English
Promotion
Recombinantタンパク質s ClearClear history
Recombinantタンパク質s CloseClose
Browse Products By Molecule Name a-zA-Z
TL1A Hot |GMP IL-2 Hot |FcRn Binding Kit (TR-FRET) New |Claudin 18.2
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
phone
Your Position: ホーム > Protein > Her2 > HE2-C82E3

Biotinylated Cynomolgus Her2 / ErbB2 Protein, His,Avitag™ (MALS verified)

INTRODUCTION
QC & Assay Protocol
Citation & Background
  • Synonym
    ERBB2,CD340,HER-2,neu,HER2,MLN19,NEU,NGL,TKR1
  • Source
    Biotinylated Cynomolgus Her2, His,Avitag(HE2-C82E3) is expressed from human 293 cells (HEK293). It contains AA Thr 23 - Thr 652 (Accession # XP_005584091.2).
    Predicted N-terminus: Thr 23
    Request for sequence
  • Molecular Characterization
    Her2 Structure

    This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™)

    The protein has a calculated MW of 72.9 kDa. The protein migrates as 90-105 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Labeling
    Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.
  • Protein Ratio
    Passed as determined by the HABA assay / binding ELISA.
  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Her2 SDS-PAGE

Biotinylated Cynomolgus Her2, His,Avitag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS
Her2 MALS images

The purity of Biotinylated Cynomolgus Her2, His,Avitag (Cat. No. HE2-C82E3) is more than 90% and the molecular weight of this protein is around 90-100 kDa verified by SEC-MALS.

Report
Bioactivity-ELISA
Her2 ELISA

Immobilized Trastuzumab Biosimilar at 3 μg/mL (100 μL/well) can bind Biotinylated Cynomolgus Her2, His,Avitag (Cat. No. HE2-C82E3) with a linear range of 0.2-8 ng/mL (QC tested).

Protocol
Her2 ELISA

Immobilized Bispecific Antibody (Her2 × Her3) at 1 μg/mL (100 μL/well) can bind Biotinylated Cynomolgus Her2, His,Avitag (Cat. No. HE2-C82E3) with a linear range of 0.2-8 ng/mL (Routinely tested).

Protocol
Her2 ELISA

Immobilized Pertuzumab Biosimilar at 1 μg/mL (100 μL/well) can bind Biotinylated Cynomolgus Her2, His,Avitag (Cat. No. HE2-C82E3) with a linear range of 0.2-8 ng/mL (Routinely tested).

Protocol
  • Background
    Human Epidermal growth factor Receptor 2 (HER2) is also called ERBB2, HER-2,HER-2 /neu, NEU, NGL,TKR1 and c-erb B2,and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2 is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. HER2 is thought to be an orphan receptor, with none of the EGF family of ligands able to activate it. Approximately 30% of breast cancers have an amplification of the HER2 gene or overexpression of its protein product. Overexpression of this receptor in breast cancer is associated with increased disease recurrence and worse prognosis. HER2 appears to play roles in development, cancer, communication at the neuromuscular junction and regulation of cell growth and differentiation .
  • Clinical and Translational Updates

コメント (0)


ETD of in-stock products: 4 business days

価格(JPY) : 98,000

価格(JPY) : 425,600

Bulk Inquiry 製品のカスタマイズ
人気商品のおすすめ
ストレプトアビジンコートプレート

価格(JPY) : 8,960

価格(JPY) : 38,360

ストレプトアビジン-HRP

価格(JPY) : 14,000

価格(JPY) : 33,600

Magnetic Beads™ 磁気ビーズ

価格(JPY) : 38,640

価格(JPY) : 64,400

一括購入 製品のカスタマイズ

Antibody Licensing

more

プロモーション＆展示



医薬品開発状況

  • Number of Launched Drugs：34 Details
  • Number of Drugs in Clinical Trials：202 Details
  • Latest Research Phase：Approved
ほかの製品について

データシート＆ドキュメンテーション

DMF請求
DMF (Drug Master File)

お問い合わせ

+1  800-810-0816 (US)
+86 400-682-2521 (AP)
全ての代理店を表示する

関連製品一覧

新製品

お問い合わせ＆コメント

This web search service is supported by Google Inc.

totopphone
Call us
お問い合わせ
グローバル：+1 800-810-0816(Toll Free)
日本：+(0)81-50-547-99099
Email
メールアドレス
order.jp@acrobiosystems.com
Fax
ファックス
+1 888-377-6111
Address
株式会社アクロバイオシステムズ
〒157-0066
東京都世田谷区成城1丁目26番9-101号

アクロバイオシステムズの公式アカウント

linkedin twitter facebook youtube

お問い合わせ（半角英文字で入力してください）

Copyright © 2017 ACROBiosystems. All Rights Reserved
Related Links|Privacy Policy|Terms and Conditions|Legal|Sitemap