ログイン 会員登録
icon_bulk_order一括注文 Acrobiosystems for English
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
phone
Your Position: ホーム > Protein > Alpha-synuclein > ALN-H5116

Human Alpha-Synuclein (A53T) Protein, Tag Free (MALS verified)

  • Synonym
    NACP, PARK1, PARK4, PD1
  • Source
    Human Alpha-Synuclein (A53T), Tag Free(ALN-H5116) is expressed from E. coli cells. It contains AA Met 1 - Ala 140 (Accession # P37840-1 (A53T)).
    Predicted N-terminus: Met 1
  • Molecular Characterization
    Alpha-synuclein Structure

    This protein carries no "tag".

    The protein has a calculated MW of 14.5 kDa. The protein migrates as 15 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Supplied as 0.2 μm filtered solution in 50 mM HEPES, 100 mM NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Shipping

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • Storage

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 months under sterile conditions.
SDS-PAGE
Alpha-synuclein SDS-PAGE

Human Alpha-Synuclein (A53T), Tag Free on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

SEC-MALS
Alpha-synuclein MALS images

The purity of Human Alpha-Synuclein (A53T), Tag Free (Cat. No. ALN-H5116) is more than 90% and the molecular weight of this protein is around 12-18 kDa verified by SEC-MALS.

Bioactivity-ELISA
 Alpha-synuclein ELISA

Immobilized Human Alpha-Synuclein (A53T), Tag Free (Cat. No. ALN-H5116) at 1 μg/mL (100 μL/well) can bind Anti-Synucelin alpha/beta Monoclonal Antibody with a linear range of 0.1-4 ng/mL (QC tested).

  • Background
    Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DJC5. Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinson's disease (PD). Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration.
  • Clinical and Translational Updates

コメント (0)


ETD of in-stock products: 4 business days

価格(JPY) : 78,400

価格(JPY) : 294,000

プロモーション&展示



医薬品開発状況

  • Number of Launched Drugs:0 Details
  • Number of Drugs in Clinical Trials:20 Details
  • Latest Research Phase:Phase 3 Clinical

データシート&ドキュメンテーション

DMF請求
DMF (Drug Master File)

関連製品一覧

新製品

お問い合わせ&コメント

This web search service is supported by Google Inc.

totopphone