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Human MICA (24-309) Protein, Fc Tag (MALS verified)

  • Synonym
    MIC-A
  • Source
    Human MICA (24-309) Protein, Fc Tag(MIA-H5254) is expressed from human 293 cells (HEK293). It contains AA Glu 24 - Thr 309 (Accession # Q29983-1).
    Predicted N-terminus: Glu 24
  • Molecular Characterization
    MICA Structure

    This protein carries a human IgG1 Fc tag at the C-terminus

    The protein has a calculated MW of 59.4 kDa. The protein migrates as 80-95 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
MICA SDS-PAGE

Human MICA (24-309) Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

SEC-MALS
MICA MALS images

The purity of Human MICA (24-309) Protein, Fc Tag (Cat. No. MIA-H5254) is more than 85% and the molecular weight of this protein is around 140-165 kDa verified by SEC-MALS.

Bioactivity-ELISA
 MICA ELISA

Immobilized Human MICA (24-309) Protein, Fc Tag (Cat. No. MIA-H5254) at 1 μg/mL (100 μL/well) can bind Human NKG2D, Mouse IgG2a Fc Tag (Cat. No. NKD-H5259) with a linear range of 0.01-0.156 μg/mL (QC tested).

 MICA ELISA

Immobilized Human NKG2D, His Tag (Cat. No. NKD-H5245) at 2 μg/mL (100 μL/well) can bind Human MICA (24-309) Protein, Fc Tag (Cat. No. MIA-H5254) with a linear range of 0.1-2 ng/mL (Routinely tested).

  • Background
    MHC class I polypeptide-related sequence A (MICA) belongs to the MHC class I family and MIC subfamily. MICA contains one Ig-like C1-type (immunoglobulin-like) domain. Unlike classical MHC class I molecules, MICA does not form a heterodimer with beta-2-microglobulin. MICA acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. MICA is ligand for the KLRK1/NKG2D receptor. MICA bind to KLRK1 leads to cell lysis.
  • Clinical and Translational Updates

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価格(JPY) : 98,000

価格(JPY) : 711,200

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