Limited Edition Golden Llama is here! Check out how you can get one. 
Limited Edition Golden Llama is here! Check out how you can get one.
Offering SPR-BLI Services - Proteins provided for free! Offering SPR-BLI Services - Proteins provided for free!
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Here come GMP Grade Cytokines！Free Sample is available！ Here come GMP Grade Cytokines！Free Sample is available！
| Product | Size | Amount |
| ActiveMax® Human CD19 μBeads, premium grade (for cells) | 2.5 mg | 2.5 × 10⁷ beads |
| ActiveMax® Human CD19 μBeads, premium grade (for cells) | 10 mg (2.5 mg × 4) | 1.0 × 10⁸ beads |
See Certificate of Analysis (CoA) for detailed instruction.
Please contact us for detailed information.
Contact us for customized product form or formulation.
Assay of human CD19 protein on the μBeads surface by Flow cytomtry. The human CD19 conjugated on the μBeads (Cat. No. MBS-C002) surface were fluorescently stained using PE labeled anti-human CD19 antibody and analyzed by flow cytometry (QC tested).
ActiveMax® Human CD19 μBeads, premium grade (for cells) (Cat. No. MBS-C002) can activate CD19-specific CAR-T cells by detecting the secretion of IFN- γ in vitro (Routinely tested).
CD19 CAR-T cells were stimulated with ActiveMax® Human CD19 μBeads (MBS-C002) for 24 h , and cell-free supernatants were harvested for evaluating IFN-γ secretion by ELISA. The results showed that CD19 CAR-T cells released significantly larger amounts of IFN-γ into the supernatants in response to CD19 μBeads . Seed the CD19 μBeads in 96-well plates at a density of 2×10⁴ μBeads/well, and co-culture with CD19 CAR-T cells at an effector-to-target (E:T) ratio of 5:1, 1:1, 1:5 in 96-well tissue culture plate, respectively. CD19 CAR-T cells alone were cultured as the control.
CD19 CAR-T cells were stimulated with ActiveMax® Human CD19 μBeads (MBS-C002) for 24 h , and cell-free supernatants were harvested for evaluating IFN-γ secretion by flow cytomtry. The results showed that CD19 CAR-T cells released significantly larger amounts of IFN-γ into the supernatants in response to CD19 μBeads. Seed the CD19 μBeads in 96-well plates at a density of 2×10⁴ μBeads/well, and co-culture with CD19 CAR-T cells at an effector-to-target (E:T) ratio of 5:1, 1:1, 1:5 in 96-well tissue culture plate, respectively. CD19 CAR-T cells alone were cultured as the control.
CD19 CAR-T cells were stimulated with ActiveMax® Human CD19 μBeads (MBS-C002) for 24h, and cells were harvested for evaluating CD69,CD137 expression by flow cytometry. The results showed that the proportion of CD69 and CD137 in CD19 CAR-T cells was significantly increased after CD19 μBeads stimulation.
Seed the CD19 μBeads in 96-well plates at a density of 2×10⁴ μBeads/well, and co-culture with CD19 CAR-T cells at an effector-to-target (E:T) ratio of 5:1, 1:1, 1:5 in 96-well tissue culture plate, respectively. CD19 CAR-T cells alone were cultured as the control.
CD19 CAR-T cells were stimulated with ActiveMax® Human CD19 μBeads (MBS-C002) for 24h, and cell-free supernatants were harvested for evaluating Granzyme B, Perforin secretion by ELISA. The results showed that CD19 CAR-T cells released significantly larger amounts of Granzyme B, Perforin into the supernatants in response to CD19 μBeads.
Seed the CD19 μBeads in 96-well plates at a density of 2×10⁴ μBeads/well, and co-culture with CD19 CAR-T cells at an effector-to-target (E:T) ratio of 5:1, 1:1, 1:5 in 96-well tissue culture plate, respectively. CD19 CAR-T cells alone were cultured as the control.
After positive selection with the ActiveMax Human CD19 ubeads at 2:4 (beads : cells), the proportion of CAR cells that enriched cells were ≈150-fold higher than that of the initial population - 0.1%.
To simulate difficult enrichment conditions, used CAR cells with low CAR expression. CAR cells in initial stained populations were rare (~ 0.1%). CD19 CAR-T cells were stimulated with ActiveMax® Human CD19 μBeads (MBS-C002) for 24 h. Transfer the tube on a magnet to separate the beads-CAR-T cells from the solution. Carefully pipette off the supernatant to a new tube, this is the unlabeled cell fraction. Wash isolated beads-cells complex (enriched CAR-T cells). Remove the tube from the magnet, resuspend the isolated beads-cells complex and then analyzed with FACS.
価格(USD) : 2390.00
価格(USD) : 5875.00
ACROBiosystemsは、二重特異性抗体の治療薬への臨床開発を加速するために、高い生物活性を持つ均一なCD3δ/CD3εおよびCD3γ/CD3εタンパク質のシリーズを開発しました。
We offer a wide range of cell and gene therapy solutions starting from discovery to the clinic. Explore our wide range of proteins, antibodies, kits, and other assays to accelerate the development of your cell and gene therapy.
Organoid Toolbox は、即使用可能のオルガノイド、オルガノイド分化ツールキット、創薬プロジェクトの進行を加速する、さまざまなサービスを含むオルガノイドソリューションのことです。
IL-15、IL-7、IL-21など、高品質のGMP準拠サイトカイン製品を提供しており、免疫細胞治療薬の臨床研究をサポートし、医薬品規制当局の承認を加速できます。
注目されている50以上のCAR-Tターゲットがあり、CARの発現の検出のために設計された抗原タンパク質をフローサイトメトリーで検証し、CARの発現が高い特異性で検出できます。ロット間の一貫性が保証されています。また、PE / FITC標識タンパク質を利用することで、ワンステップ染色でCARの発現を高い特異性でバックグラウンドなしに検出できます。
GMP準拠サイトカイン、高品質の細胞活性化/増幅試薬、遺伝子改変試薬/酵素、CAR検出試薬などの製品を提供し、細胞、遺伝子治療用に全体的なソリューションを提供し、創薬から臨床研究までのすべての段階をサポートします。
CD20、Claudin18.2、CD133、GPRC5D、CCR5、CCR8などの安定で高活性な全長型膜貫通タンパク質は、免疫学、ELISA、SPR、BLI、細胞実験、CAR陽性率検出に利用できます。VLP、界面活性剤、ナノディスクなどのテクニカルプラットフォームによって複数回膜貫通タンパク質の医薬品創薬を促進できます。
これまでに知られている免疫チェックポイント分子をほぼ製品化しており、様々なタグの製品群を提供できます。天然高分子の構造はMALSによって、生物活性はELISA/SPR/BLI/FACSなどによって検証済みです。またBiotin/FITCなどの標識も選択でき、抗体のハイスループットスクリーニングに利用できます。
弊社ACROBiosystemsはADC医薬品の開発のサポートに取り組み、注目されている様々なターゲットのために、異なる種類とタグの製品が開発され、高い純度と親和性が特長です。免疫、抗体スクリーン、SPR、細胞活性検査などの実験に利用できます。Protocolも無償で提供いたします。
すべての分子のFc受容体タンパク質だけでなく、一般的な変異体やビオチン標識タイプも含まれております。お客様のモノクローナル抗体の開発をサポートします。
インターロイキン、成長因子、ケモカイン、TNF など、様々なサイトカインターゲットの自然なコンフォメーションを確保するために HEK293 によって発現されます。SDS-PAGE/HPLC/SEC-MALS によって高純度は確認され、高い生物活性は ELISA/SPR/BLI によって確認されています。
AneuroはACROBiosystemsが神経科学研究のために設計した製品群のブランドです。神経科学研究を推進するための治療・診断用研究タンパク質、PFF、組み換え神経因子など、高品質の重要なタンパク質を提供しております。
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